{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:32:55Z","timestamp":1791567175035,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019720","name":"GlaxoSmithKline Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015613","name":"Centre hospitalier r\u00e9gional universitaire de Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030962","name":"H\u00f4pital Foch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample\u2010size and\/or follow\u2010up duration are available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE\/HES [HE\/HES\u2010R], idiopathic HES [HES\u2010I], lymphocytic HES [HES\u2010L], neoplastic HE\/HES [HE\/HES\u2010N], HE of unknown significance [HE\u2010US], as well as IgG4\u2010related disease [IgG4RD] or ANCA\u2010negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps). Patients are followed\u2010up yearly. All data about final diagnosis, organ involvement assessments, and outcome profiles in HES\u2010I were captured and analyzed centrally by HES expert centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From May 2019 to November 2023, 779 patients were included. For this preliminary analysis, 550 cases were available for centralized review (mean\u2009\u00b1\u2009SD age: 56\u2009\u00b1\u200918\u2009years, 42% of female patients). The final diagnoses were HES\u2010I (47%), HE\/HES\u2010R (16%), HE\u2010US (15%), HE\/HES\u2010N (7%), HE\/HES\u2010L (6%), IgG4RD (2%), and ANCA\u2010negative EGPA (7%). In the 258 HES\u2010I patients, outcome profiles were classified as follows: 16.3% had a \u201csingle\u2010flare\u201d without further relapse, 28.3% had a \u201crelapsing\u2013remitting\u201d disease when there was at least a 6\u2010month period free of symptoms between two flares, 46.1% had a \u201cpersistent disease\u201d requiring continuous treatment to avoid relapses (9.3% remained unclassified because of insufficient follow\u2010up).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The COHESion cohort is the first nationwide prospective multicenter study collecting data on the full spectrum of HE\/HES disorders. This preliminary analysis confirms that idiopathic HES patients have various outcome profiles, suggesting different underlying pathophysiological mechanisms and the need of patient\u2010specific management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT 04018118\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16463","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T02:55:33Z","timestamp":1736132133000},"page":"1100-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort"],"prefix":"10.1111","volume":"80","author":[{"given":"Guillaume","family":"Lef\u00e8vre","sequence":"first","affiliation":[{"name":"Institut d'Immunologie, Service de m\u00e9decine Interne et d'immunologie Clinique, CHU Lille, INFINITE\u2014Institute for Translational Research in Inflammation Universit\u00e9 de Lille  Lille France"},{"name":"Centre de R\u00e9f\u00e9rence des Syndromes Hyper\u00e9osinophiliques (CEREO)  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Bleuse","sequence":"additional","affiliation":[{"name":"Institut d'Immunologie, Service de m\u00e9decine Interne et d'immunologie Clinique, CHU Lille, INFINITE\u2014Institute for Translational Research in Inflammation Universit\u00e9 de Lille  Lille France"},{"name":"Centre de R\u00e9f\u00e9rence des Syndromes Hyper\u00e9osinophiliques (CEREO)  Suresnes 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