{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:53Z","timestamp":1787013833396,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal barrier dysfunction may lead to a break in tolerance and development of food allergy (FA). There is contradictory evidence on whether intestinal permeability (IP) is altered in IgE\u2010mediated FA. Thus, we sought to determine whether IP differed between children with eczema who did (FA group) or did not (atopic controls, ACs) develop FA and whether peanut sensitization, allergy, and early introduction impacted IP using serum biomarkers zonulin, soluble CD14, and Intestinal Fatty Acid Binding Protein among randomly selected participants enrolled in the Learning Early About Peanut allergy trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FA group was defined as having at least one FA at either baseline (4\u201311\u2009months) or 60\u2009months of age (V60). ACs had eczema at baseline and no FA at either visit. Serum IP markers (sIPMs) were measured by ELISA at baseline and V60, and their relationship with the clinical characteristics of participants was analyzed using parametric tests and linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We evaluated 237 FA subjects and 76 ACs. sIPM levels were similar in FA subjects and ACs at baseline and V60. Age when the child first developed any FA (&lt;\u20091\u2009year vs. &gt;\u20091\u2009year), eczema severity, peanut sensitization, peanut allergy, and early peanut introduction were not statistically significantly associated with sIPM levels. Total IgE and eosinophil levels, peanut\u2010specific IgE, IgG4, and IgG4\/IgE ratio were not correlated with sIPM levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No differences in sIPMs were detected to support altered IP in infants with FA compared to ACs or following early peanut introduction among peanut\u2010sensitized children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16464","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:25:11Z","timestamp":1736749511000},"page":"2286-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-319X","authenticated-orcid":false,"given":"Ozge Nur","family":"Aktas","sequence":"first","affiliation":[{"name":"Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health  Bethesda Maryland USA"},{"name":"Division of Allergy and Immunology Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-478X","authenticated-orcid":false,"given":"Allyson","family":"Mateja","sequence":"additional","affiliation":[{"name":"Clinical Monitoring Research Program Directorate Frederick National Laboratory for Cancer Research  Frederick Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-289X","authenticated-orcid":false,"given":"Min (Jenny)","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9598-949X","authenticated-orcid":false,"given":"Lindsay","family":"Chatman","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6642-1603","authenticated-orcid":false,"given":"Megan C.","family":"Grieco","sequence":"additional","affiliation":[{"name":"Biostatistics Research Branch, NIAID, NIH  North Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-7160","authenticated-orcid":false,"given":"Carolyn H.","family":"Baloh","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Immune Tolerance Network Benaroya Research Institute at Virginia Mason  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4768-5126","authenticated-orcid":false,"given":"Michelle","family":"Huffaker","sequence":"additional","affiliation":[{"name":"Immune Tolerance Network Benaroya Research Institute at Virginia Mason  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-5223","authenticated-orcid":false,"given":"Lisa M.","family":"Wheatley","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases National Institute of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-2928","authenticated-orcid":false,"given":"George","family":"du Toit","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"Pediatric Allergy Group, Department of Women and Children's Health, School of Life Course and Population Sciences King's College London  London UK"},{"name":"Children's Allergy Service Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7350-4021","authenticated-orcid":false,"given":"Gideon","family":"Lack","sequence":"additional","affiliation":[{"name":"Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"Pediatric Allergy Group, Department of Women and Children's Health, School of Life Course and Population Sciences King's College London  London UK"},{"name":"Children's Allergy Service Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3370-6598","authenticated-orcid":false,"given":"Erica","family":"Brittain","sequence":"additional","affiliation":[{"name":"Biostatistics Research Branch, NIAID, NIH  North Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-5546","authenticated-orcid":false,"given":"Pamela A.","family":"Frischmeyer\u2010Guerrerio","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(81)92459\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_834_21"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204385"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.06.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100307"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.717925"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102019\u2010318427"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13158"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)02169\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12194"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010022\u201002334\u20106"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1745918"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7754\/clin.lab.2014.140518"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.03.037"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13798"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201007242\u20104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1511"},{"issue":"102","key":"e_1_2_11_20_1","first-page":"1","article-title":"CD14 as A Serum Immune Biomarker and Genetic Predisposition Factor for Allergic Rhinitis","volume":"31","author":"Zare Marzouni H.","year":"2019","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20101592.1998.00103.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/738563"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PG9.0000000000000070"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.12.002"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13979"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05\u20101593"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015831\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519863133"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000735"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2848"},{"issue":"5","key":"e_1_2_11_32_1","first-page":"127","article-title":"Measurement of Intestinal Permeability to Mannitol and Lactulose as a Means of Diagnosing Food Allergy and Evaluating Therapeutic Effectiveness of Disodium Cromoglycate","volume":"59","author":"Andre C.","year":"1987","journal-title":"Annals of Allergy"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.1986.tb01993.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.1994.tb00816.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.1993.tb00071.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00788.x"},{"issue":"3","key":"e_1_2_11_37_1","first-page":"87","article-title":"The Intestinal Permeability Test Applied to the Diagnosis of Food Allergy in Paediatrics","volume":"43","author":"Laudat A.","year":"1994","journal-title":"West Indian Medical Journal"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.1984.tb02207.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450\u2010198808000\u201000012"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.123535"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010243141"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2004.00191.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.056"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.05.019"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.043"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.016"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010019\u20100987\u20100"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010023\u201001097\u2010y"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210728"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00022"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.16464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:56:29Z","timestamp":1771167389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.16464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/all.16464"],"URL":"https:\/\/doi.org\/10.1111\/all.16464","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.172114446.64484440\/v1","asserted-by":"object"}]},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"2024-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}