{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:04Z","timestamp":1792428004758,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alarmin cytokine IL\u201025 promotes type 2 inflammatory responses in disorders such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and known targets include ILC2 and Th2 cells. However, other cellular targets for IL\u201025 remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate induction and expression of IL\u201025 receptor (IL\u201017RB) by B cells and evaluate responsiveness of IL\u201017RB\u2010expressing B cells to IL\u201025 in\u00a0vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>IL\u201017RB expression, regulation and function on B cells were evaluated in peripheral blood\u2010derived B cells by flow cytometry and RT\u2010PCR, including in response to IgE\u2010inducing stimuli (anti\u2010CD40 mAb and IL\u20104). Single\u2010cell RNA sequencing was used to compare IL\u201017RB+ and IL\u201017RB\u2010activated peripheral blood\u2010derived B cells. To evaluate B cell IL\u201017RB expression within type 2 inflamed tissue, B cells were compared from nasal polyps, control turbinate tissue and matched peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Activation of B cells with anti\u2010CD40 and IL\u20104 increased IL\u201017RB expression at both protein and mRNA level, which was further upregulated by IL\u201025. B cells induced to express IL\u201017RB responded to IL\u201025 with enhanced antibody production. Single\u2010cell RNA\u2010sequencing showed that IL17RB+ activated B cells expressed higher levels of IGHE, CCL17 and CCL22 compared to IL17RB\u2010 B cells. B cells from nasal polyp tissue expressed higher levels of surface IL\u201017RB compared with control tissue, correlating with patient\u2010reported CRSwNP severity (SNOT\u201022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peripheral blood B cells activated under IgE\u2010inducing conditions express surface IL\u201017RB, and tissue IL\u201017RB+ B cells are increased in type 2 inflammation. IL\u201017RB+ cells have a distinct transcriptional profile and respond to IL\u201025 with enhanced antibody production, highlighting the IL\u201025\/IL\u201017RB pathway as a potential therapeutic target for CRSwNP and other type 2 inflammatory disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16472","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:26:33Z","timestamp":1737339993000},"page":"965-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>IL<\/scp>\n                    \u201025 Enhances B Cell Responses in Type 2 Inflammation Through\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>17RB<\/scp>\n                    Receptor"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-3464","authenticated-orcid":false,"given":"Semah","family":"Abdu","sequence":"first","affiliation":[{"name":"School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"King's Centre for Lung Health King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-2950","authenticated-orcid":false,"given":"Jiao","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"ENT Department, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"Department of Immunology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-0680","authenticated-orcid":false,"given":"Tiak Ju","family":"Tan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-1806","authenticated-orcid":false,"given":"Janice A.","family":"Layhadi","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-3463","authenticated-orcid":false,"given":"Mohamed H.","family":"Shamji","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-2512","authenticated-orcid":false,"given":"Andrew N. 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