{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:18:19Z","timestamp":1784647099454,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473512"],"award-info":[{"award-number":["82473512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real\u2010world settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with moderate\u2010to\u2010severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow\u2010up period of at least 16\u2009weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP\u2010NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI\/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 73 PN patients (33 female, 40 male; mean age 45.9\u2009\u00b1\u200921.5\u2009years) were included. A clinically meaningful improvement of \u2265\u20094 points in PP\u2010NRS (PP\u2010NRS4) was achieved in 84.9% of patients at Week 12. The percentage of patients achieving IGA 0\/1 significantly increasing from 0% to 37.0% and 46.6% at Week 12 and 16, respectively. Patient\u2010reported quality of life outcomes showed substantial improvement, with decreasing from 16.6\u2009\u00b1\u20096.8 at baseline to 7.2\u2009\u00b1\u20094.9 at Week 12, 6.4\u2009\u00b1\u20094.5 at Week 16. The safety profile of dupilumab was favorable, with one patient reporting dry eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dupilumab can effectively improve the pruritus, nodular lesions and quality of life for PN in real\u2010world settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16478","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T14:51:20Z","timestamp":1737471080000},"page":"1428-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-6050","authenticated-orcid":false,"given":"Zuotao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Tianjin Institute of Integrative Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-4402","authenticated-orcid":false,"given":"Xiaoting","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology General Hospital of Ningxia Medical University  Yinchuan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Allergy Tangshan Gongren Hospital  Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-1241","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songmei","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University  Xian 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