{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:37:17Z","timestamp":1787315837534,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014000","name":"Masonic Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a clinical setting is unreported. We assessed the feasibility of point\u2010of\u2010care (POC) eosinophil measurements in preschool wheezers and related BEC to symptoms, lung function, and utility in predicting attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children aged 1\u20135\u2009years with recurrent wheeze underwent finger\u2010prick sampling during the outpatient clinic for POC eosinophils, forced oscillation technique (FOT) and\/or spirometry, and symptom score (TRACK questionnaire). The utility of BEC and\/or the other tests in predicting wheeze attacks in the subsequent 3\u2009months was analysed by comparing those with and without an attack and using a predictive decision tree (DT) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010three children (median age 4.27\u2009years) were recruited; BEC were higher in atopic children (median 0.5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L vs. 0.3\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L non\u2010atopic,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). BEC moderately correlated with FOT reactance bronchodilator reversibility\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score changes (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.495,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), but no other lung function measures or TRACK score.\n                    <\/jats:p>\n                    <jats:p>\n                      68\/73 (93%) children were followed up at 3\u2009months. 29\/68 (43%) children had &gt;\u20091 wheeze attack requiring unscheduled healthcare attendance. Absolute and %eosinophils at the baseline visit were higher in those who had an attack (median 0.5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L vs. 0.3\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03 and median 6% vs. 4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The DT model showed children with BEC \u2265\u20094% and TRACK score &lt;\u200975 were more likely to have a future attack (probability 0.63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>POC blood eosinophils were feasible in a clinical setting. Our preliminary data suggest elevated BEC with a low symptom score predicts a wheeze attack within 3\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16500","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:10:32Z","timestamp":1740031832000},"page":"1038-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Point\u2010of\u2010Care Blood Eosinophils to Predict Preschool Wheeze Attacks"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-288X","authenticated-orcid":false,"given":"Kushalinii","family":"Hillson","sequence":"first","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fontanella","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernani","family":"Almeida","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pavlou","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katariina","family":"Lajunen","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital and University of Turku, Lighthouse Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Irving","sequence":"additional","affiliation":[{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Testa","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Bingham","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-4422","authenticated-orcid":false,"given":"Karina Mayoral","family":"Oritz","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Lacbay","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hay","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Gore","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-4174","authenticated-orcid":false,"given":"Elizabeth","family":"Scotney","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Paraskakis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Heraklion University Hospital, University of Crete Medical School  Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-223X","authenticated-orcid":false,"given":"Samatha","family":"Sonnappa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-7433","authenticated-orcid":false,"given":"Louise","family":"Fleming","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-9822","authenticated-orcid":false,"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"},{"name":"Centre for Paediatrics &amp; Child Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-6418","authenticated-orcid":false,"given":"Sejal","family":"Saglani","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London  London UK"},{"name":"Department of Respiratory Paediatrics Royal Brompton Hospital  London UK"},{"name":"Centre for Paediatrics &amp; 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