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Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway. The Rhinology Group, Chinese Society of Otorhinolaryngology\u2010Head and Neck Surgery; the Rhinology Group, Chinese Medical Doctor Association of Otorhinolaryngology\u2010Head and Neck Surgery; and the Nasal and Ocular Allergy Group, Chinese Society of Allergy have convened an expert panel consisting of principal investigators experienced in clinical trials of biologic treatment for CRSwNP. This expert panel was assembled to discuss the application of biologic agents in patients with CRSwNP in China. Additionally, the latest findings on the pathogenesis of CRSwNP, mechanisms of biologic agents, and efficacy and safety of biologic treatment in patients with CRSwNP were reviewed, with a special emphasis on research evidence from China. The expert panel reached a consensus on several critical issues, including criteria for the prescription, treatment course, and efficacy evaluation from a Chinese perspective. This position paper aims to guide Chinese physicians in the use of biologic agents for patients with CRSwNP. As our experience with biologic treatment continues to grow, this position paper will be further updated.<\/jats:p>","DOI":"10.1111\/all.16519","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T22:00:16Z","timestamp":1741212016000},"page":"1208-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-6314","authenticated-orcid":false,"given":"Mu","family":"Xian","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of New Medicine and Diagnostic Technology Research for Nasal Disease, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of New Medicine and Diagnostic Technology Research for Nasal Disease, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital, Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Otolaryngology Department The First People's Hospital  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Second Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; 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