{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:29:01Z","timestamp":1787632141967,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Monkeypox virus (mpox) outbreak since 2022 has already constituted a public health emergency of international concern. A comprehensive study on epidemiological features, symptoms and signs, complications, sequelae, and clinical outcomes has been lacking. Accordingly, we performed a large\u2010scale multicenter study to comprehensively summarize the clinical, epidemiological, behavioral, laboratory, virological characteristics, and treatment\u2010related outcomes of mpox in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this multicenter hospital\u2010based retrospective study, demographic information, clinical characteristics, laboratory results, hospitalization records, prescribed medications, and clinical outcomes were extracted from the electronic medical records of 286 confirmed mpox cases from five regions of China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>An approximately 1:1 ratio of HIV\u2010positive (52.1%) and HIV\u2010negative was found, with an overall median age of 32\u2009years (IQR 27\u201337). Most patients were male (99.3%), lived in urban areas (86.0%), single (72.6%), and had a college degree or higher (62.0%). Men having sex with men (MSM) was the predominant sexual orientation (83.0%), and sexual contact was the most likely mode of exposure (85.4%). 17 (9.6%) patients reported a history of smallpox vaccination. Hundered and seven patients had at least one co\u2010morbid other sexually transmitted infection. Fourteen patients had a self\u2010reported history of allergy. Significant differences were found between HIV\u2010negative and HIV\u2010positive mpox in the proportion of MSM, anal and perianal pain, levels of AST, CRP, CD4+ T\u2010cell, CD8+ T\u2010cell, NK\u2010cell levels, and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MSM individuals with an interquartile age range of 27\u201337\u2009years, particularly from coastal or developed regions of China, were identified as \u201cmain affected population\u201d for mpox prevention and control. HIV infection may contribute to more severe mpox manifestations, characterized by elevated AST and CRP levels, reduced CD4\u2009+\u2009T\u2010cell and NK\u2010cell counts, and unfavorable clinical outcomes with increased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.16540","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T21:44:39Z","timestamp":1744062279000},"page":"1436-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical, Epidemiological, Virological Characteristics and Outcomes of 286 Patients Infected With Monkeypox Virus in China"],"prefix":"10.1111","volume":"80","author":[{"given":"Hankun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University  Wuhan China"},{"name":"Hubei Micro\u2010Explore Innovative Pharmaceutical Research Co., Ltd  Wuhan Hubei China"},{"name":"Suzhou Organ\u2010On\u2010a\u2010Chip System Science and Technology Co., Ltd  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianguo","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Second People's Hospital, Tianjin Institute of Hepatology, Clinical School of the Second People's Hospital, Tianjin Medical University  Nankai, Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Hubei Center of Diseases Control and Prevention  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaokai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chongqing Public Health Medical Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Wuhan University Taikang Medical School  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Chen","sequence":"additional","affiliation":[{"name":"Yichang Third People's Hospital  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Ping","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Pharmacy Peking University Cancer Hospital &amp; 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