{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:04:08Z","timestamp":1792015448521,"version":"4.4.0"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Regulatory T cells (Tregs) are living drugs with feasibility, tolerability, and therapeutic benefits. Although Tregs are linked to asthma prognosis through inflammation regulation, no therapeutic agents specifically designed to manage asthma by upregulating Tregs have been developed to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened a library of 250 natural products using a cytometric bead array. Among the selected candidates, gRb1 was identified for further investigation. The effects of gRb1 on Treg and Th17 populations were evaluated in mouse asthma models and human PBMCs from both healthy donors and asthma patients using flow cytometry and cytokine analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In inflammatory conditions, ginsenoside Rb1 (gRb1, a major ginseng component) increased IL\u201010\u2010 and TGF\u2010\u03b2\u2010expressing Treg populations and decreased the Th17 population; activated phospho\u2010STAT5 and NFAT1 in Tregs; inhibited NFAT1 activation in conventional T cells (Tconvs); increased Treg proliferation and Tconv\u2013Treg differentiation, inhibiting Tconv proliferation; and reduced inflammatory cytokine secretion by Tconvs. In asthma model mice, suppression of asthma symptoms by gRb1 was associated with elevated Treg and lower Th17, Th1, and Th2 counts. gRb1 treatment of stimulated PBMCs from patients with asthma and healthy donors increased IL\u201010\u2010 and TGF\u2010\u03b2\u2010expressing Treg populations and decreased IL\u201017A\u2010, IL\u201022\u2010, IFN\u2010\u03b3\u2010, and TNF\u2010\u03b1\u2010expressing T\u2010cell populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>gRb1 alleviate asthma by shifting the Treg\u2013inflammatory T cell balance. These findings suggest a strategy for enhancing Treg activity through treatment with gRb1. This may provide a novel therapeutic approach for asthma and related disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16551","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T03:53:36Z","timestamp":1745034816000},"page":"1647-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Asthma Alleviation by Ginsenoside Rb1 via Promotion of Treg Proliferation and Inflammatory T Cell Inhibition"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-1754","authenticated-orcid":false,"given":"Susanna","family":"Choi","sequence":"first","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Ah","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Medical Life Sciences College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kon\u2010Young","family":"Ji","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-5720","authenticated-orcid":false,"given":"Dong Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saseong","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Integrative Rheumatoid Transcriptomics and Dynamics College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2010Gu","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Integrative Rheumatoid Transcriptomics and Dynamics College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Myo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University College of Medicine, Seoul National University Boramae Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Young","family":"Lee","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010A","family":"Jung","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Jeong","family":"Pyun","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Hur","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Kook","family":"Rhee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Integrative Rheumatoid Transcriptomics and Dynamics College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Biomedicine &amp; 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