{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:27Z","timestamp":1791221667958,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019573","name":"Amsterdam University Medical Centers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002066","name":"GlaxoSmithKline foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Patients with Non\u2010steroidal anti\u2010inflammatory drugs (\n NSAID<\/jats:styled-content>\n )\u2010Exacerbated Respiratory Disease (N\u2010\n ERD<\/jats:styled-content>\n ) can suffer from difficult\u2010to\u2010treat primary diffuse type 2 chronic rhinosinusitis with nasal polyps (\n CRSwNP<\/jats:styled-content>\n ). This study evaluates dupilumab effectiveness and dose tapering in\n CRSwNP<\/jats:styled-content>\n patients with N\u2010\n ERD<\/jats:styled-content>\n compared to those without.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A real\u2010world prospective cohort with\n CRSwNP<\/jats:styled-content>\n patients, with N\u2010\n ERD<\/jats:styled-content>\n or without (\n CRSwNP<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n ; not otherwise specified), aged \u2265\u200918 treated with dupilumab 300\u2009mg subcutaneously every 2\u2009weeks. In case of clinical control, the interdose interval was prolonged every 6\u2009months with steps of 2\u2009weeks. (Clinical) data were collected at baseline, 24\u2009weeks, and 2\u2009years of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most baseline characteristics, including Nasal Polyp Score (\n NPS<\/jats:styled-content>\n ), Sino\u2010Nasal Outcome Test\u201022 (\n SNOT<\/jats:styled-content>\n \u201022), and Sniffin\u2032 sticks\u201012 test (\n SSIT<\/jats:styled-content>\n \u201012) were comparable between groups (N\u2010\n ERD<\/jats:styled-content>\n n<\/jats:italic>\n \u2009=\u2009105,\n CRSwNP<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n n<\/jats:italic>\n \u2009=\u2009293). There was a higher prevalence (91.5% vs. 71.1%,\n p<\/jats:italic>\n \u2009<\u20090.001) but comparable control of asthma in N\u2010\n ERD<\/jats:styled-content>\n patients (asthma control test [\n ACT]<\/jats:styled-content>\n : N\u2010\n ERD<\/jats:styled-content>\n 66.7% less controlled\/uncontrolled vs.\n CRSwNP<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n 58.3%,\n p<\/jats:italic>\n \u2009=\u20090.21). All outcomes improved significantly with dupilumab treatment at 24\u2009weeks and remained improved after 2\u2009years, without intergroup differences (median scores at 24\u2009weeks for N\u2010\n ERD<\/jats:styled-content>\n patients vs.\n CRSwNP<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n , respectively:\n NPS<\/jats:styled-content>\n : 2 vs. 1,\n p<\/jats:italic>\n \u2009=\u20090.65;\n SNOT<\/jats:styled-content>\n \u201022: 18 vs. 19,\n p<\/jats:italic>\n \u2009=\u20090.27;\n SSIT<\/jats:styled-content>\n \u201012: 7 vs. 8,\n p<\/jats:italic>\n \u2009=\u20090.02;\n ACT<\/jats:styled-content>\n : 21 vs. 22,\n p<\/jats:italic>\n \u2009=\u20090.11). Dose tapering was possible in the majority of patients, with almost half at an 8\u201312\u2009weeks interval in both groups after 2\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Dupilumab shows comparable effectiveness and taper feasibility between\n CRSwNP<\/jats:styled-content>\n N\u2010\n ERD<\/jats:styled-content>\n patients and\n CRSwNP<\/jats:styled-content>\n \u2010\n NOS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.16579","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:02:02Z","timestamp":1747386122000},"page":"1737-1745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Two\u2010Year Data of Tapered Dupilumab Shows High Effectiveness in Chronic Rhinosinusitis with Nasal Polyps With Nonsteroidal Anti\u2010inflammatory Drug\u2010Exacerbated Respiratory Disease"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-6018","authenticated-orcid":false,"given":"H. B. E.","family":"Elzinga","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5437-3005","authenticated-orcid":false,"given":"J. J.","family":"Otten","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Cornet","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Alrijne Hospital Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Rinia","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Isala Hospital Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. L.","family":"Van Der Lans","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-229X","authenticated-orcid":false,"given":"W. J.","family":"Fokkens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-2632","authenticated-orcid":false,"given":"S.","family":"Reitsma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PolyREG Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13599"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1514013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00905-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1487"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0673-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.12.027"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.11.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.734000"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2016.06.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.032"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00097-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15772"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin23.357"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"403","article-title":"Steroid Responsiveness Predicts Olfactory Function Recovery in Dupilumab Treated CRSwNP","volume":"62","author":"Otten J. 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