{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:14:47Z","timestamp":1785838487831,"version":"3.56.0"},"reference-count":114,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This systematic review evaluated the association between lower respiratory tract infections (LRTI) in infancy with respiratory syncytial virus (RSV), rhinovirus (RV) or infestation with helminths and the risk of developing asthma and allergic diseases. The risk of bias was assessed with ROBINS\u2010E, and the certainty of evidence (CoE) with GRADE. Meta\u2010analysis applied a random\u2010effects model. RSV LRTI is likely associated with an increased risk of developing asthma by age 7 (OR 3.02, 95% CI 2.23\u20134.09;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200998%; moderate CoE). The impact on wheezing, atopic dermatitis (AD), and allergic rhinitis is uncertain. RV LRTI may be associated with increased risk of developing asthma (OR 8.40, 95% CI 2.56\u201327.55;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200943%; low CoE). The impact on wheezing and AD is uncertain.\n                    <jats:italic>Trichuris trichiura<\/jats:italic>\n                    infestation might be associated with reduced risk of new\u2010onset wheezing (OR 0.57, 95% CI 0.35\u20130.94; very low CoE) or AD (HR: 0.35, 95% CI 0.18\u20130.67; very low CoE). The association between\n                    <jats:italic>Ascaris lumbricoides<\/jats:italic>\n                    and hookworm infestation and the risk of developing asthma or AD is uncertain. Infestation with any helminths might be associated with reduced risk of new\u2010onset asthma by age 5 (OR: 0.60, 95% CI 0.38\u20130.95; very low CoE) and wheezing (OR 0.70, 95% CI 0.51\u20130.95; very low CoE). More high\u2010quality studies are needed to confirm these findings.\n                  <\/jats:p>","DOI":"10.1111\/all.16611","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T01:43:42Z","timestamp":1749606222000},"page":"1878-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Impact of Rhinovirus, Syncytial Respiratory Virus and Helminth Infection on the Risk of New\u2010Onset Asthma and Other Allergic Conditions\u2014A Systematic Review for the\n                    <scp>EAACI<\/scp>\n                    Guidelines on Environmental Science for Allergic Diseases and Asthma"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-364X","authenticated-orcid":false,"given":"Ioana","family":"Agache","sequence":"first","affiliation":[{"name":"Faculty of Medicine Transylvania University  Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Salazar","sequence":"additional","affiliation":[{"name":"Iberoamerican Cochrane Centre  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesenia","family":"Rodriguez\u2010Tanta","sequence":"additional","affiliation":[{"name":"Iberoamerican Cochrane Centre  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella Karina Fernandez","family":"Saenz","sequence":"additional","affiliation":[{"name":"Iberoamerican Cochrane Centre  Barcelona Spain"},{"name":"Institut de Recerca Sant Pau (IR SANT PAU)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-2156","authenticated-orcid":false,"given":"Tari","family":"Haahtela","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-5179","authenticated-orcid":false,"given":"Claudia","family":"Traidl\u2010Hoffmann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Environmental Medicine and Integrative Health University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-5667","authenticated-orcid":false,"given":"Athanasios","family":"Damialis","sequence":"additional","affiliation":[{"name":"Terrestrial Ecology and Climate Change, Department of Ecology, Faculty of Sciences, School of Biology Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Vecillas","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital La Paz Institute for Health Research (IdiPAZ)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-6882","authenticated-orcid":false,"given":"Mattia","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Allergy Unit Meyer Children's Hospital IRCCS  Florence Italy"},{"name":"Department of Health Sciences University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-2955","authenticated-orcid":false,"given":"Kari C.","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Department of Environmental Health John Rock Professor of Climate and Population Studies  Boston USA"},{"name":"Center for Climate, Health, and the Global Environment Harvard T.H. 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