{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:21:29Z","timestamp":1787883689975,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dysbiosis is increasingly linked to allergy development. This study evaluates the efficacy of the multi\u2010strain probiotic SYN\u201053 in the management of allergic rhinoconjunctivitis (ARC). Eighty\u2010four subjects with confirmed grass pollen allergy underwent up to three bi\u2010weekly 3\u2010day intake cycles with SYN\u201053 or placebo. After each cycle, subjects were exposed to grass pollen in an allergen exposure chamber. ARC symptoms were assessed using the Total Symptom Score (TSS) before and after each use of SYN\u201053. After one intake cycle, SYN\u201053 already showed a trend towards greater efficacy over placebo, which became significant after two cycles (\u0394TSS\n                    <jats:sub>MAX<\/jats:sub>\n                    : \u22123.44\u2009\u00b1\u20090.42 vs. \u22121.87\u2009\u00b1\u20090.37;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0067), with 38% vs. 24% symptom relief. In subjects with moderate to severe symptoms, SYN\u201053 was already significantly superior after one single intake cycle and improved further after two cycles (\u0394TSS\n                    <jats:sub>MAX<\/jats:sub>\n                    : \u22124.78\u2009\u00b1\u20090.51 vs. \u22122.43\u2009\u00b1\u20090.47;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0014), with 45% vs. 26% symptom relief. SYN\u201053 is effective in the management of ARC, highlighting the role of bacterial diversity and dosage in probiotic nutritional supplements.\n                  <\/jats:p>","DOI":"10.1111\/all.16634","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T12:38:54Z","timestamp":1751027934000},"page":"2158-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of the Multi\u2010Strain Probiotic\n                    <scp>SYN<\/scp>\n                    \u201053 in the Management of Allergic Rhinoconjunctivitis"],"prefix":"10.1111","volume":"80","author":[{"given":"Karl\u2010Christian","family":"Bergmann","sequence":"first","affiliation":[{"name":"Institute of Allergology Charit\u00e9 Universit\u00e4tsmedizin  Berlin Germany"},{"name":"Corporate Member of Freie Universit\u00e4t Berlin Humboldt Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-8875","authenticated-orcid":false,"given":"Torsten","family":"Zuberbier","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9 Universit\u00e4tsmedizin  Berlin Germany"},{"name":"Corporate Member of Freie Universit\u00e4t Berlin Humboldt Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939\u20104551\u20107\u201012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12130"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.03.028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000227\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12470"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000359963"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010213"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1243632"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934\u2010020\u201001430\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510536"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025091"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010022\u201008939\u20109"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/frmbi.2024.1418633"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2025.100362"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.11.038"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.570"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10101904"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2017.04.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.848279"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2022.111300"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211073550"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v50i3.507"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2025.101954"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1286006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14183"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12383"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.041"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098656"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2010.02473.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.025"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14331"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.16634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.16634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:55:49Z","timestamp":1771167349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.16634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/all.16634"],"URL":"https:\/\/doi.org\/10.1111\/all.16634","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"2025-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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