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The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs). The most common reported reactions to these drugs are cutaneous, such as exanthemas associated with thienopyridine and urticaria\/angioedema by aspirin, which can also induce respiratory symptoms. APDs other than aspirin, particularly ticlopidine, can also cause hematologic reactions consisting mainly of isolated thrombocytopenia, agranulocytosis, and leukopenia. Immune\u2010mediated reactions to aspirin are very rare. Few data suggest the usefulness of skin testing in patients with cutaneous reactions to APDs other than aspirin, particularly clopidogrel. Therefore, the drug provocation test is the gold standard for diagnosing hypersensitivity to APDs. Low\u2010dose aspirin challenge (i.e., up to 150\u2013180\u2009mg) and aspirin desensitization have emerged as effective and safe approaches in patients with suspected or confirmed aspirin hypersensitivity who require aspirin therapy. Both, a short course of oral glucocorticoids without interruption of clopidogrel treatment and desensitization, appears to be effective and safe options in patients with cutaneous HSRs to clopidogrel. This position paper provides data and recommendations regarding the characteristics of HSRs to APDs and related diagnostic procedures in order to make them as safe and effective as possible. Management and treatment options, including desensitization protocols, are also provided.<\/jats:p>","DOI":"10.1111\/all.16663","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:39:32Z","timestamp":1753353572000},"page":"2973-2987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-6366","authenticated-orcid":false,"given":"Gabriele","family":"Cortellini","sequence":"first","affiliation":[{"name":"Allergy Unit Azienda Sanitaria Della Romagna  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-6361","authenticated-orcid":false,"given":"Alla","family":"Nakonechna","sequence":"additional","affiliation":[{"name":"Chest and Allergy Clinic Imperial College Healthcare NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1589","authenticated-orcid":false,"given":"Annick","family":"Barbaud","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Dermatologie et Allergologie, Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP Sorbonne Universit\u00e9, H\u00f4pital Tenon  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-0830","authenticated-orcid":false,"given":"Sevim","family":"Bavbek","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Chest Diseases Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-3755","authenticated-orcid":false,"given":"Gianfranco","family":"Calogiuri","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Interdivisional Service Ospedale Civile Vito Fazzi  Lecce Italy"},{"name":"Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology University of Bari Aldo Moro  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-4878","authenticated-orcid":false,"given":"Inmaculada","family":"Do\u00f1a","sequence":"additional","affiliation":[{"name":"Allergy Unit and Research Group Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA Plataforma BIONAND, ARADyAL  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-211X","authenticated-orcid":false,"given":"Violeta","family":"Kvedariene","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences and Institute of Clinical Medicine, Faculty of Medicine  Vilnius Lithuania"},{"name":"Institute of Clinical Medicine, Vilnius University Hospital Santariskiu Klinikos, Innovative Allergology Center  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-8979","authenticated-orcid":false,"given":"Jose Julio","family":"Laguna Martinez","sequence":"additional","affiliation":[{"name":"Allergy Unit, Allergo\u2010Anaesthesia Unit Faculty of Medicine, Hospital Central de la Cruz Roja, Alfonso X El Sabio University, ARADyAL, REI  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-8265","authenticated-orcid":false,"given":"Serena","family":"Liberati","sequence":"additional","affiliation":[{"name":"Allergy Unit Azienda Sanitaria Della Romagna  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-5416","authenticated-orcid":false,"given":"Mauro","family":"Pagani","sequence":"additional","affiliation":[{"name":"Medicine Department, Medicine Ward Mantova Hospital ASST di Mantova  Mantova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-9898","authenticated-orcid":false,"given":"Antonino","family":"Romano","sequence":"additional","affiliation":[{"name":"Oasi Research Institute\u2014IRCCS  Troina Italy"},{"name":"BIOS S.p.A. 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