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N\u2010ERD increases the risk for severe hypersensitivity reactions, recurring sinonasal surgeries, or the need for systemic corticosteroid treatment. Aspirin (ASA) treatment after desensitization (ATAD) is a treatment option for N\u2010ERD. Desensitization to ASA is reached with increasing ASA doses over a few days, followed by a long\u2010term treatment. This study evaluated the efficacy of ATAD with an ASA dose of 250\u2009mg in adult CRSwNP patients with asthma and N\u2010ERD. Forty\u2010one CRSwNP patients with comorbid asthma and N\u2010ERD were recruited for this randomized double\u2010blind clinical trial. Twenty\u2010six patients had successful ASA desensitization, were randomized into placebo and ASA arms, and continued to 11\u2009months of daily ASA, with a target dose of 250\u2009mg. The outcome measures, including Sino\u2010Nasal Outcome Test 22 (SNOT\u201022), nasal polyp score (NPS), Asthma Control Test (ACT), and EPOS 2012 CRS clinical control assessment, were evaluated at control visits at 1, 5, 11, and 12\u2009months after the start of the treatment. In the linear mixed effects model,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010values for the combined effect of group and time showed no difference between placebo and ATAD for SNOT\u201022, ACT, and NPS, with\n                    <jats:italic>p<\/jats:italic>\n                    \u2010values 0.17, 0.45, and 0.18, respectively. Neither group showed significant improvement in the EPOS 2012 CRS control assessment. In conclusion, no significant clinical difference was observed between ATAD and placebo in the treatment of CRSwNP patients with asthma and N\u2010ERD.\n                  <\/jats:p>","DOI":"10.1111\/all.16679","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:25:34Z","timestamp":1753773934000},"page":"3151-3164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Aspirin Therapy After Desensitization on Chronic Rhinosinusitis With Nasal Polyps Patients With Asthma and Non\u2010steroidal Anti\u2010inflammatory Drug Exacerbated Respiratory Disease \u2014A Randomized Clinical Trial"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7289-358X","authenticated-orcid":false,"given":"Alma","family":"Helev\u00e4","sequence":"first","affiliation":[{"name":"Department of Allergology, Inflammation Center Helsinki University Hospital and 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