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Whether TSLP or IL\u201033 have a role in EoE and whether their activities are distinct requires further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Experimental EoE was induced in wild type (WT)\n                      <jats:italic>Il33<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>Crlf2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice. TSLP or IL\u20105 were neutralized using antibodies. Esophageal histopathology was determined by H&amp;E, anti\u2010Ki67, anti\u2010CD31, and anti\u2010MBP staining. Esophageal RNA was subjected to RNA sequencing. Bone marrow\u2010derived MCs were activated with TSLP and IL\u201013 was determined (ELISA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TSLP and IL\u201033 were overexpressed in human and experimental EoE. Human and mouse esophageal MCs displayed the highest level of\n                      <jats:italic>Crlf2<\/jats:italic>\n                      (TSLPR) compared to other immune cells.\n                      <jats:italic>Crlf2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice were nearly completely protected from EoE, and TSLP neutralization resulted in decreased basal cell proliferation, eosinophilia, lamina propria thickening, and vascularization. Induction of experimental EoE in\n                      <jats:italic>Il33<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice resulted in reduced eosinophilia, but no alterations in tissue remodeling were observed compared to WT mice. RNA sequencing revealed that TSLP regulates the expression of key genes associated with human EoE (e.g., eotaxins,\n                      <jats:italic>Il19<\/jats:italic>\n                      ,\n                      <jats:italic>Klk5<\/jats:italic>\n                      ,\n                      <jats:italic>Flg<\/jats:italic>\n                      ,\n                      <jats:italic>Il36rn<\/jats:italic>\n                      ,\n                      <jats:italic>Il1r2<\/jats:italic>\n                      ) and suggests a role for TSLP in regulating IL\u20101 signaling, barrier integrity, and epithelial cell differentiation. Experimental EoE was characterized by a MC\u2010associated gene signature and elevated MCs. Activation of MCs with TSLP resulted in the secretion of IL\u201013.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TSLP and IL\u201033 have non\u2010redundant functions in experimental EoE. This study highlights TSLP as an upstream regulator of IL\u201013 and a potential therapeutic target for EoE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.16682","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:44:37Z","timestamp":1753775077000},"page":"3095-3107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Distinct Roles for Thymic Stromal Lymphopoietin (\n                    <scp>TSLP<\/scp>\n                    ) and\n                    <scp>IL<\/scp>\n                    \u201033 in Experimental Eosinophilic Esophagitis"],"prefix":"10.1111","volume":"80","author":[{"given":"Anish","family":"Dsilva","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medical and Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv 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