{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:44:11Z","timestamp":1783197851228,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["UN112\u20100020"],"award-info":[{"award-number":["UN112\u20100020"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["UN111\u20100056"],"award-info":[{"award-number":["UN111\u20100056"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["IBMS\u2010CRC112\u2010P02"],"award-info":[{"award-number":["IBMS\u2010CRC112\u2010P02"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Commonly used to treat inflammatory skin diseases, narrowband ultraviolet B (UVB) has been shown to induce antigen\u2010specific immune suppression when combined with alloantigen immunization, but the underlying mechanism remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used cytometry by time\u2010of\u2010flight (CyTOF) to analyze the peripheral blood mononuclear cells (PBMCs) from 19 psoriasis patients enrolled in UVB trial. Mouse models of ovalbumin (OVA)\u2010induced skin inflammation and allogeneic skin transplantation were used to investigate the effects of UVB on antigen\u2010specific regulatory T cell (Treg) induction. We applied bulk RNA sequencing (RNA\u2010seq) and single\u2010cell RNA sequencing (scRNA\u2010seq) methods to the analyses of mouse skin Tregs and PBMCs, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CyTOF analysis revealed patients\u2019 therapeutic response to be determined by a cluster of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells expressing T cell receptor (TCR)\u2010activated and Treg\u2010associated molecules. In clinical trial and mouse models of skin inflammation and allogeneic skin transplantation, UVB led to immunosuppressive phenotypes through antigen\u2010specific Treg induction. RNA\u2010seq from mouse skin Tregs showed that UVB enhanced gene expression associated with cell stability, cellular location, and cell proliferation. When compiling with human peripheral Tregs analyzed by scRNA\u2010seq, we found similar gene expression patterns involved in Treg differentiation, maintenance, and function. Furthermore, scRNA\u2010seq analysis also demonstrated that UVB inhibited negative regulators of Treg development, thereby promoting CD4\n                      <jats:sup>+<\/jats:sup>\n                      T differentiation into Tregs, clonal expansion of which was also noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest UVB can induce antigen\u2010specific Tregs in a clinical setting, highlighting its potential for broader immunosuppressive applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70019","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T06:21:22Z","timestamp":1755930082000},"page":"373-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Narrowband Ultraviolet B Induces Peripheral Regulatory T Cells to Exert Antigen\u2010Specific Immune Suppression"],"prefix":"10.1111","volume":"81","author":[{"given":"Chun\u2010Hao","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hui","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iquo O.","family":"Phillip","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8057-4621","authenticated-orcid":false,"given":"Pei\u2010Chuan","family":"Chiang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-286X","authenticated-orcid":false,"given":"Shao\u2010Han","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Jui","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Medical University\u2010Shuang Ho Hospital  New Taipei City Taiwan"},{"name":"Department of Dermatology, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u2010Hui","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"},{"name":"Department of Dermatology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsen\u2010Fang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-9479","authenticated-orcid":false,"given":"Yungling Leo","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  Taipei Taiwan"},{"name":"College of Public Health China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24165"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007024"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.124.1.445"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.3.781"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198807000-00021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2007.11.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701056"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308063"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01018.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00775.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2554"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120914"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070719"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.029"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10772"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911756107"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003130"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1544409"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13626"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.042"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1672537"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0185-9"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107784"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10149.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.10.001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw2707"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80367-2"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00032.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00128-0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23475"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36594-x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00336.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601617103"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.052"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040896"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00488"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.26"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10991"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19380"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1005115"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.104985"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:19:38Z","timestamp":1770023978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/all.70019"],"URL":"https:\/\/doi.org\/10.1111\/all.70019","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}