{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:53Z","timestamp":1787013833401,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404125"],"award-info":[{"award-number":["82404125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830095"],"award-info":[{"award-number":["81830095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23PJ1408100"],"award-info":[{"award-number":["23PJ1408100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eczematous eruption (EE) is an adverse effect observed in psoriasis patients undergoing interleukin (IL)\u201017A inhibitor therapy, with reported incidence rates ranging from 2.2% to 12.1%. In some cases, this reaction leads to discontinuation of treatment. However, the underlying mechanism of EE development remains unclear. Therefore, we aimed to elucidate the pathogenesis of EE associated with anti\u2010IL\u201017A treatment and identify pathogenic molecules involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Skin samples were collected from psoriasis patients both before and after anti\u2010IL\u201017A treatment, and the treated skin included those with and without EE. Transcriptomic profiling was performed using bulk RNA\u2010seq and scRNA\u2010seq, which were further validated by histopathological analysis and protein assay. In addition, in\u00a0vitro experiments were conducted to explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bulk RNA\u2010seq analysis revealed significantly elevated IL\u201021 expression in EE lesions, along with marked enrichment of Th2\/Th22 pathways and activation of JAK\u2013STAT signaling compared to baseline and non\u2010EE samples. Immunohistochemistry confirmed increased expression of IL\u201021, pJAK1, and pSTAT3 in EE lesions. ELISA and LEGENDplex assays detected higher levels of IL\u201021, IL\u201013, and IL\u201022, with positive correlations between IL\u201021 and the latter two cytokines. ScRNA\u2010seq localized IL\u201021 expression predominantly to T cells within EE lesions, which co\u2010expressed high levels of IL\u201013 and IL\u201022. In\u00a0vitro, rhIL\u201021 stimulation activated JAK1\/STAT3 signaling and increased IL\u201013 and IL\u201022 secretion, which were suppressed by JAK1 inhibition. These findings identify IL\u201021 as an important regulator of Th2\/Th22 responses and JAK\u2013STAT signaling in EE pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201021 is an important inflammatory mediator contributing to the development of EE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70026","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:25:08Z","timestamp":1756470308000},"page":"1697-1708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevated Cutaneous Interleukin\u201021 Links Eczematous Eruption to Interleukin\u2010\n                    <scp>17A<\/scp>\n                    Inhibitor Treatment in Psoriasis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-5045","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Ruijin\u2010Yatsen Joint Laboratory, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-9735","authenticated-orcid":false,"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Ruijin\u2010Yatsen Joint Laboratory, Ruijin Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 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