{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:09Z","timestamp":1792270629179,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab is an effective treatment for severe, uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Most real\u2010life studies have been conducted on small patient cohorts for up to 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This ambispective, multicentric, 2\u2010year\u2010long study evaluated dupilumab effectiveness (including treatment response, disease control, and remission) and safety in severe, uncontrolled CRSwNP patients from the DUPIREAL Italian study centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study involved 926 patients. At 24\u2009months, median nasal polyp score (NPS), nasal obstruction visual analogue scale (VAS), Sino\u2010nasal Outcome Test\u201022 (SNOT\u201022), and olfaction improved from baseline (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Patients with NPS &gt;\u20094, and\/or SNOT\u201022 &gt;\u200930, and\/or Sniffin\u2019 Sticks Identification Test\u201016 (SSIT\u201016) &lt;\u200912 at 12\u2009months demonstrated improvements in these outcomes over the second year. Overall, 18.7% of patients extended the dupilumab interdose interval to every 4\u2009weeks (q4w). Notably, 91.2% of patients were \u201cgood\u2010to\u2010excellent\u201d responders based on EPOS\/Euforea criteria. Given the absence of standardized definitions for disease control and remission, we proposed different sets of criteria reporting results from different scenarios. Remission analysis is clinically important as it helps define treatment success and long\u2010term therapeutic goals. Most adverse events were mild\u2010to\u2010moderate; 2.4% of patients discontinued treatment due to safety concerns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the largest real\u2010life study evaluating dupilumab in CRSwNP over 2\u2009years. Dupilumab showed sustained effectiveness, with progressive improvements across all clinical outcomes. Dupilumab tapering did not compromise outcomes; treatment continuation allowed meaningful clinical benefits in late responders. Two\u2010year rates of disease control and remission are clinically relevant, although standardized criteria to assess these outcomes are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70032","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T08:30:44Z","timestamp":1756542644000},"page":"388-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Two\u2010Year Turning Point With Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Control, Remission, and Tapering Dosage"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De Corso","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-0314","authenticated-orcid":false,"given":"Claudio","family":"Montuori","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"},{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-2117","authenticated-orcid":false,"given":"Carlotta","family":"Pipolo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Health Sciences, ASST Santi Paolo e Carlo Hospital Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-273X","authenticated-orcid":false,"given":"Ignazio","family":"La Mantia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, ENT Section University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-0387","authenticated-orcid":false,"given":"Ernesto","family":"Pasquini","sequence":"additional","affiliation":[{"name":"ENT Unit Bellaria Hospital, Azienda USL Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-1901","authenticated-orcid":false,"given":"Angelo","family":"Ghidini","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department IRCCS Arcispedale Santamaria Nuova  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-8034","authenticated-orcid":false,"given":"Veronica","family":"Seccia","sequence":"additional","affiliation":[{"name":"Otolaryngology, Audiology and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine Azienda Ospedaliera Universitaria Pisana, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-4761","authenticated-orcid":false,"given":"Giancarlo","family":"Ottaviano","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7389-2033","authenticated-orcid":false,"given":"Elena","family":"Cantone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive and Odontostomatological Sciences\u2010ENT Section University of Naples Federico II  Naples Italy"},{"name":"Head and Neck Department\u2010ENT Section AOU Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7905-7260","authenticated-orcid":false,"given":"Giulia","family":"Dan\u00e9","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Head and Neck Department, IRCCS San Raffaele Scientific Institute Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Garzaro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology Unit Eastern Piedmont University \u2013 Maggiore Hospital  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-7291","authenticated-orcid":false,"given":"Gian Luca","family":"Fadda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology San Luigi Gonzaga Hospital, University of Turin  Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Torretta","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico\u201d University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Anastasi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Ospedale San Giovanni Evangelista  Tivoli, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Rikki Mauritz","family":"Canevari","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit IRCCS Policlinico San Martino Genova, Dipartimento DISC Universit\u00e0 di Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-373X","authenticated-orcid":false,"given":"Fabio","family":"Pagella","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Lucidi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Azienda Ospedaliero Universitaria di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-8935","authenticated-orcid":false,"given":"Carlo","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Pagliuca","sequence":"additional","affiliation":[{"name":"Otolaryngology University Unit \u201cS. M. Goretti Hospital\u201d  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Maffei","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Unit AORN Ospedali Della Colli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-2772","authenticated-orcid":false,"given":"Francesco","family":"Bussu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"},{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria di Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Corb\u00f2","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"},{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Maria","family":"D\u2032Auria","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"De Maio","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Loperfido","sequence":"additional","affiliation":[{"name":"Otolaryngology Unit San Camillo Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Gallo","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Head and Neck Department ASST Sette Laghi  Varese Italy"},{"name":"UPLOAD (Upper and Lower Airways Diseases) Research Centre  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"D\u2032Agostino","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Giannarelli","sequence":"additional","affiliation":[{"name":"Design and Analysis of Clinical Trials Unit, Scientific Directorate Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-4573","authenticated-orcid":false,"given":"Jacopo","family":"Galli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit A. Gemelli University Hospital Foundation IRCCS  Rome Italy"},{"name":"Department of Head, Neck and Sensory Organs Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DUPIREAL Italian Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.01.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"301","article-title":"Dupilumab Reduces Systemic Corticosteroid Use and Sinonasal Surgery Rate in CRSwNP","volume":"59","author":"Desrosiers M.","year":"2021","journal-title":"Rhinology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102684"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091526"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12081215"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15772"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13020234"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16357"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16263"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.10.016"},{"issue":"3","key":"e_1_2_11_13_1","first-page":"287","article-title":"EPOS2020\/EUFOREA Expert Opinion on Defining Disease States and Therapeutic Goals in CRSwNP","volume":"62","author":"Fokkens W. J.","year":"2024","journal-title":"Rhinology"},{"issue":"3","key":"e_1_2_11_14_1","first-page":"194","article-title":"EPOS\/EUFOREA Update on Indication and Evaluation of Biologics in Chronic Rhinosinusitis With Nasal Polyps 2023","volume":"61","author":"Fokkens W. J.","year":"2023","journal-title":"Rhinology"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"144","article-title":"The Relationship Between Subjective Assessment Instruments in Chronic Rhinosinusitis","volume":"45","author":"Lim M.","year":"2007","journal-title":"Rhinology"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"229","article-title":"Individual Symptom Visual Analogue Scale Severity Scores for Determining EPOS Guideline\u2010Based Chronic Rhinosinusitis Disease Control","volume":"60","author":"Phillips K. M.","year":"2022","journal-title":"Rhinology"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.07.026"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15796"},{"issue":"15","key":"e_1_2_11_19_1","first-page":"7324","article-title":"Severe Chronic Rhinosinusitis Treated With Dupilumab, a Real\u2010Life Analysis of Early Effectiveness","volume":"27","author":"Mocellin D.","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.32162"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-023-01118-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13111531"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2024.10.014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010291"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201008725\u20107"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:19:47Z","timestamp":1770023987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/all.70032"],"URL":"https:\/\/doi.org\/10.1111\/all.70032","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}