{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:43:07Z","timestamp":1773006187457,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["IITP\u20102024\u2010RS\u20102024\u201000438239"],"award-info":[{"award-number":["IITP\u20102024\u2010RS\u20102024\u201000438239"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000509257"],"award-info":[{"award-number":["RS\u20102024\u201000509257"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent previous study suggests that live zoster vaccination may reduce the risk of diseases like dementia and cardiovascular diseases, through prevention of herpes zoster. Thus, this study aims to evaluate whether live zoster vaccination can reduce the risk of chronic respiratory disease including chronic obstructive pulmonary disease (COPD), asthma, and interstitial lung disease (ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This target trial emulation study utilized a nationwide, population\u2010based cohort of 2,519,582 individuals aged \u2265\u200950\u2009years in South Korea. The cohort was constructed by integrating health insurance data from the Korea Health Insurance Review and Assessment Service, national health examination data from the Korean National Health Insurance Service, and vaccination records from the Korea Disease Control and Prevention Agency. The exposure was receipt of at least one dose of live zoster vaccination between January 1, 2012, and December 31, 2021. Outcomes included the incidence of newly diagnosed COPD, asthma, and ILD, as well as hospitalizations associated with these conditions. Following stabilized inverse probability of treatment weighting, we employed the Cox proportional hazards model to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) and calculated restricted mean survival time (RMST) for the risk of outcomes associated with live zoster vaccination. The observation period extends from the index date to January 31, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>After stabilized inverse probability of treatment weighting, 745,644 individuals were assigned to the vaccinated group and 1,069,230 to the unvaccinated group, with a mean age of 62.12\u2009years (SD, 3.45) and 49.18% were male. Live zoster vaccination significantly reduced the risk of COPD (aHR, 0.70 [95% CI, 0.69\u20130.71]; RMST difference, 23.22\u2009days [95% CI, 21.72\u201324.71]), asthma (0.68 [0.67\u20130.69]; 25.96\u2009days [24.52\u201327.40]) and ILD (0.78 [0.73\u20130.82]; 2.39\u2009days [2.05\u20132.74]). Additionally, the vaccination significantly reduced the risk of hospital admissions due to these conditions: COPD (0.59 [0.53\u20130.65]), asthma (0.54 [0.49\u20130.59]), and ILD (0.68 [0.58\u20130.79]). The observed protective benefit was more pronounced in non\u2010smokers compared to current smokers. The time\u2010attenuated effect was strongest during 1 to 2\u2009years following live zoster vaccination and remained evident for up to 6\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Live zoster vaccination significantly reduced the incidence of chronic respiratory disease and related hospitalizations. These findings suggest that live zoster vaccination may provide public health benefits beyond preventing herpes zoster in adults aged \u2265\u200950\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70056","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:39:56Z","timestamp":1758195596000},"page":"209-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Live Zoster Vaccination and the Reduced Risk of Chronic Respiratory Diseases: An Emulated Target Trial"],"prefix":"10.1111","volume":"81","author":[{"given":"Tae Hyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Precision Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Regulatory Science Kyung Hee University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Medicine CHA University School of Medicine  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyeon","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sooji","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Health, Performance and Wellbeing Anglia Ruskin University  Cambridge UK"},{"name":"Department of Public Health Faculty of Medicine, Biruni University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-3877","authenticated-orcid":false,"given":"Francesco","family":"Branda","sequence":"additional","affiliation":[{"name":"Unit of Medical Statistics and Molecular Epidemiology Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Kyung Hee University  Yongin South Korea"},{"name":"Department of Electronics and Information Convergence Engineering Kyung Hee University  Yongin South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Biomedical Engineering Kyung Hee University  Yongin South Korea"},{"name":"Department of Electronics and Information Convergence Engineering Kyung Hee University  Yongin South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9948","authenticated-orcid":false,"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute Kyung Hee University Medical Center, Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Precision Medicine Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Regulatory Science Kyung Hee University  Seoul South Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul South Korea"},{"name":"Department of Biomedical Engineering Kyung Hee University  Yongin South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4029"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076321"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz652"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhip.2025.100592"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00039-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08800-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf230"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27781"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1389823"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.08.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00151-X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47176-w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02051-3"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48825-w"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41516-y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100601"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-024-01895-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2009.00671.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032788"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.04.004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00470-6"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00506-3"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101333"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.10.009"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.666045"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.01.007"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01052-2"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1731-0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw854"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw047"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu918"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(22)00227-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10020303"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16071137"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06968-8"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216566"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.016"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2024.06.018"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101936"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29740"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaf105"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac549"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23-2023"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:50:43Z","timestamp":1771167043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/all.70056"],"URL":"https:\/\/doi.org\/10.1111\/all.70056","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}