{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:54:10Z","timestamp":1792662850455,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interleukin\u201018 (IL\u201018) is a pleiotropic cytokine implicated in atopic dermatitis (AD), affecting both type (T)1 and T2 immune pathways. An anti\u2013IL\u201018 monoclonal antibody, aletekitug, was evaluated for its clinical and molecular effects in patients with moderate to severe AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomised, double\u2010blind, parallel\u2010group, placebo\u2010controlled, 24\u2010week study assessed adults with moderate\u2010to\u2010severe AD who were biologic\u2010na\u00efve or dupilumab\u2010inadequate responders\/intolerant. Participants received a single intravenous (IV) infusion of aletekitug 2\u2009mg\/kg or placebo. The primary endpoint was percentage change from baseline (PCFB) in Eczema Area and Severity Index (EASI) score at Week 12. Other endpoints included safety, patient\u2010reported outcomes (PROs) and transcriptomics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four participants (aletekitug,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) were randomised. A greater reduction in the PCFB in EASI score at Week 12 was demonstrated for patients who received aletekitug versus placebo (posterior median PCFB [95% credible intervals]: aletekitug, \u221268.3% [\u221279.68, \u221256.68]; placebo, \u221232.9% [\u221245.74, \u221221.10]), with effects still apparent at Week 24. Aletekitug improved PRO measures of itch, sleep disturbance, fatigue and quality of life versus placebo up to Week 24. Transcriptome analysis suggested aletekitug modulated lesional skin towards a non\u2010lesional profile and exerted broad immunomodulatory effects, impacting several AD\u2010associated signalling pathways, not limited to T2 immunity. Aletekitug was well tolerated, with no serious adverse events reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single 2\u2009mg\/kg IV dose of aletekitug was associated with improved outcomes at Week 12, which were sustained to Week 24, and modulated immune mechanisms beyond T2 inflammation. These results support IL\u201018 as a potential therapeutic target in moderate\u2010to\u2010severe AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70172","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:27:54Z","timestamp":1766057274000},"page":"539-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Molecular Effect of the Anti\u2013\n                    <scp>IL<\/scp>\n                    \u201018 Antibody Aletekitug in Adults With Atopic Dermatitis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-4571","authenticated-orcid":false,"given":"Joanne","family":"Ellis","sequence":"first","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Fortunato","sequence":"additional","affiliation":[{"name":"GSK  Rueil\u2010Malmaison France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Wajdner","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Del Duca","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Barnard","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-1839","authenticated-orcid":false,"given":"Joanna C.","family":"Betts","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaroop","family":"Bose","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Browning","sequence":"additional","affiliation":[{"name":"University of Texas Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Buil\u2010Bruna","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-4342","authenticated-orcid":false,"given":"Scott","family":"Van Buren","sequence":"additional","affiliation":[{"name":"GSK  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-4132","authenticated-orcid":false,"given":"Eden","family":"David","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-9604","authenticated-orcid":false,"given":"Scott","family":"Dinehart","sequence":"additional","affiliation":[{"name":"Arkansas Dermatology  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Dhawan","sequence":"additional","affiliation":[{"name":"GSK  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parima","family":"Ghafoori","sequence":"additional","affiliation":[{"name":"GSK  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiranmai","family":"Gumireddy","sequence":"additional","affiliation":[{"name":"GSK  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghong","family":"Li","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Jing","family":"Loo","sequence":"additional","affiliation":[{"name":"Western University  London Ontario Canada"},{"name":"Probity Medical Research Inc  Waterloo Ontario Canada"},{"name":"DermEffects  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-717X","authenticated-orcid":false,"given":"Fiona","family":"Lovegrove","sequence":"additional","affiliation":[{"name":"Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-2723","authenticated-orcid":false,"given":"Jenny","family":"Lowe","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence Charles","family":"Parish","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-2462","authenticated-orcid":false,"given":"Will","family":"Powley","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-4997","authenticated-orcid":false,"given":"Naveen","family":"Prasad","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Correa","family":"Da Rosa","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieta","family":"Ruseva","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Shokrian","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Syed","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-221X","authenticated-orcid":false,"given":"Chun\u2010Hang","family":"Tang","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel K.","family":"Wong","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5554-9358","authenticated-orcid":false,"given":"John B.","family":"Kelly","sequence":"additional","affiliation":[{"name":"GSK  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Wisniacki","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Uings","sequence":"additional","affiliation":[{"name":"GSK  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-324X","authenticated-orcid":false,"given":"Emma","family":"Guttman\u2010Yassky","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"11","key":"e_1_2_13_2_1","article-title":"Atopic Dermatitis","volume":"91","author":"Galli E.","year":"2020","journal-title":"Acta Bio\u2010Medica"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16003"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.006"},{"issue":"5","key":"e_1_2_13_5_1","first-page":"1","article-title":"Emerging Systemic Treatments for Atopic Dermatitis","volume":"13","author":"Ferrucci S. M.","year":"2023","journal-title":"Dermatologic Therapy"},{"issue":"11","key":"e_1_2_13_6_1","article-title":"Atopic Dermatitis: Clinical Aspects and Unmet Needs","volume":"10","author":"Lobefaro F.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.11.009"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226172"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943640"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.955369"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.011"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19574"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.01.013"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.2.151"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1005"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.945"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839195"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0201-4"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.011"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13051"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13962"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919973"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1425-y"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41180-2"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1592.2003.00290.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10145.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17088"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19153"},{"key":"e_1_2_13_30_1","unstructured":"J. B.Kelly J.Ellis L.Fortunato et\u00a0al. \u201cEfficacy Safety and Tolerability of GSK1070806 an Anti\u2013IL\u201018 Monoclonal Antibody in Patients With Moderate\u2010To\u2010Severe Atopic Dermatitis: A Randomised Double\u2010Blind Parallel\u2010Group Placebo\u2010Controlled Study \u201d Inflammatory Skin Disease Summit (ISDS) (2023)."},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202087"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150018"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247972"},{"key":"e_1_2_13_34_1","volume-title":"European Medicines Agency \u2013 Compilation of Guidelines (2021)","author":"Committee for Medicinal Products for Human Use. European Medicines Agency","year":"2020"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.010"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17932"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2855"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.053"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.025"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0079"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606490"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.043"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18898"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00388-8"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-015-0133-x"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09467.x"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.307"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S331119"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13203167"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.318"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.1169"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15913"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2012.18.7.527"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.09.278"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.2741\/2277"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00451.2010"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54559-6"},{"key":"e_1_2_13_61_1","unstructured":"\u201cClinicalTrials.gov. NCT06436183 \u201dhttps:\/\/clinicaltrials.gov\/study\/NCT06436183."},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1342176"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:19:50Z","timestamp":1770023990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/all.70172"],"URL":"https:\/\/doi.org\/10.1111\/all.70172","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}