{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:19:54Z","timestamp":1783491594785,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic spontaneous urticaria (CSU) is a debilitating skin condition affecting approximately 1% of the global population, characterized by recurrent wheals, angioedema, or both for over 6\u2009weeks without identifiable external triggers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This Phase 3b multicentre, double\u2010blinded followed by open\u2010label extension study evaluated the long\u2010term efficacy and safety of ligelizumab re\u2010treatment in patients with CSU who rolled over from previous studies. Patients from the PEARL\u20101 or PEARL\u20102 Phase 3 trials (re\u2010treatment subpopulation) received blinded re\u2010treatment with ligelizumab 72\u2009mg or 120\u2009mg every 4\u2009weeks for 12\u2009weeks, followed by open\u2010label ligelizumab 120\u2009mg up to Week 104. Patients from a Phase 3 open\u2010label Japanese study or a Phase 2 pediatric study received open\u2010label ligelizumab 120\u2009mg throughout. Primary and key secondary efficacy endpoints were assessed at Week 12 in the re\u2010treatment subpopulation; safety was evaluated throughout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the overall ligelizumab re\u2010treatment subpopulation, 53.5% and 57.5% of patients treated with ligelizumab 72\u2009mg and 120\u2009mg, respectively, achieved weekly urticaria activity score (UAS7) of \u2264\u20096 at Week 12. Re\u2010treatment efficacy was demonstrated in both treatment arms, across all secondary endpoints, maintained up to Week 52. Re\u2010treatment efficacy in the overall trial population showed similar trends to those in the re\u2010treatment subpopulation. The safety profile of ligelizumab showed no new or unexpected safety signals compared with the known safety profile of ligelizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term and re\u2010treatment with ligelizumab was well tolerated and efficacious in patients with CSU, aligning with the short\u2010term outcomes observed in the Phase 3 PEARL studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70181","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T11:45:23Z","timestamp":1765194323000},"page":"2391-2402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Efficacy and Safety of Ligelizumab as Re\u2010Treatment in Patients With Chronic Spontaneous Urticaria"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9548-5423","authenticated-orcid":false,"given":"Ana M.","family":"Gimenez\u2010Arnau","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital del Mar Research Institute Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[{"name":"Urticaria Center of Reference and Excellence (UCARE) Institute of Allergology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2011Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-3279","authenticated-orcid":false,"given":"Chia\u2010Yu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Deleanu","sequence":"additional","affiliation":[{"name":"University Medicine and Pharmacy Iuliu Hatieganu IRGH, Allergy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-2513","authenticated-orcid":false,"given":"Gordon","family":"Sussman","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Allergy, Department of Medicine, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-783X","authenticated-orcid":false,"given":"Jorge","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Group of Clinical and Experimental Allergy Hospital \u201cAlma Mater de antioquia,\u201d University of Antioquia (Medell\u00edn, Colombia)  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-3681","authenticated-orcid":false,"given":"Knut","family":"Brockow","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein, School of Medicine and Health Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koremasa","family":"Hayama","sequence":"additional","affiliation":[{"name":"Division of Cutaneous Science, Department of Dermatology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Hide","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiroshima University Hospital  Hiroshima Japan"},{"name":"Department of Dermatology Hiroshima City Hiroshima Citizens Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-2744","authenticated-orcid":false,"given":"Mohamed","family":"Denguezli","sequence":"additional","affiliation":[{"name":"Farhat Hached Hospital Dermatology Department  Sousse Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Meshkova","sequence":"additional","affiliation":[{"name":"Smolensk State Medical University Department of Clinical Immunology and Allergology  Smolensk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta F. 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