{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:54:09Z","timestamp":1766397249441,"version":"3.48.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pollen defensins such as Art v 1 (mugwort) and Amb a 4 (ragweed) are pivotal allergens in pollen\u2013food syndromes, but their clinical role in Southern Europe is poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize sensitization to defensins and related allergens in Italy and its association with clinical phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2021 and 2025, 7176 patients underwent molecular testing in three Italian centers. Sensitization to the pollen defensins Art v 1 and Amb a 4 was evaluated, together with celery allergens representing different protein families: the PR\u201010 Api g 1, the nsLTPs Api g 2, Api g 6, and the defensin Api g 7 (tested in a subset). Panallergens were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Defensin sensitization occurred in 272 patients (3.8%). Art v 1 mono\u2010sensitization (64.7%) was largely confined to respiratory disease. Dual Art v 1\u2013Amb a 4 sensitization (30.5%) identified a distinct subgroup at high risk of food reactions (OR\u2009=\u20096.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Amb a 4 sensitization followed a clear northward gradient. Among 90 patients tested for Api g 7, 82.7% were positive, all co\u2010sensitized to Art v 1, and one\u2010third also to Amb a 4. IgE inhibition confirmed Art v 1 as the primary sensitizer driving defensin cross\u2010reactivity. In contrast, Api g 2 nsLTP sensitization was strongly associated with severe systemic reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Defensin sensitization in Italy reveals distinct molecular and geographic signatures. Isolated Art v 1 sensitization dominates and marks respiratory allergy, while co\u2010sensitization to Amb a 4\u2014often associated with Api g 7 co\u2010recognition\u2014defines patients at high risk for systemic food reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70195","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:49:52Z","timestamp":1766396992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Art v 1 and Amb a 4 Co\u2010Sensitization Identifies Italian Patients at Risk for Mugwort\u2010Celery\u2010Spice Syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-9168","authenticated-orcid":false,"given":"Enrico","family":"Scala","sequence":"first","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Cusa","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Villella","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Abeni","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Giani","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma Cristina","family":"Guerra","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Locanto","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Meneguzzi","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Pirrotta","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Quaratino","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Zaffiro","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Caprini","sequence":"additional","affiliation":[{"name":"Fondazione Luigi Maria Monti IDI\u2010IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Barrale","sequence":"additional","affiliation":[{"name":"U.O.C of Clinical Pathology Buccheri La Ferla Hospital  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Brusca","sequence":"additional","affiliation":[{"name":"U.O.C of Clinical Pathology Buccheri La Ferla Hospital  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Pravettoni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione IRCCS ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-2449","authenticated-orcid":false,"given":"Lorenzo","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Unit San Giovanni di Dio Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Villalta","sequence":"additional","affiliation":[{"name":"S.C. di Immunologia e Allergologia di Laboratorio PO S. Maria Degli Angeli  Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Aumayr","sequence":"additional","affiliation":[{"name":"Macro Array Diagnostics  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mittermann","sequence":"additional","affiliation":[{"name":"Macro Array Diagnostics  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lupinek","sequence":"additional","affiliation":[{"name":"Macro Array Diagnostics  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-1700","authenticated-orcid":false,"given":"Riccardo","family":"Asero","sequence":"additional","affiliation":[{"name":"Ambulatorio di Allergologia, Clinica San Carlo  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00425-002-0902-6","article-title":"Plant Defensins","volume":"216","author":"Thomma B. 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