{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:47:05Z","timestamp":1792021625667,"version":"4.4.0"},"reference-count":99,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Asthma is a chronic inflammatory respiratory disease, affecting hundreds of millions of individuals worldwide. Mucous hypersecretion, which leads to the formation of mucous plugs within the airways, is a key pathophysiological feature associated with severe asthma and airway remodeling. Persistent airflow obstruction due to mucous plugging has been recognized as a contributor to poor symptom control in patients with asthma. This phenomenon is driven by type 2 inflammation, mediated by elevated levels of IL\u20105 and IL\u201013, as well as eosinophilic infiltration, which collectively promote the formation and persistence of mucous plugs. The presence of mucous plugging has been linked to the frequency and severity of exacerbations, as well as airflow obstruction. Imaging modalities such as high\u2010resolution computed tomography (HRCT), hyperpolarized\n                    <jats:sup>129<\/jats:sup>\n                    Xe MRI, and optical coherence tomography (OCT) have provided insights into the extent of mucous plugging and its association with airflow limitation. Over the past decade, biological therapies targeting specific pathways of type 2 inflammation have emerged as highly effective treatment options for patients with severe asthma. These therapies have conferred substantial improvements in lung function, reduction in exacerbation rates, and decreased oral glucocorticoid use. One of their mechanisms of action might be due to removal of persistent mucous plugs not achieved by conventional anti\u2010asthmatic therapies such as inhaled corticosteroids (ICS) and oral corticosteroids (OCS). This comprehensive review summarizes the effects of biologics on mucous plugging in severe asthma, focusing on their mechanisms of action, clinical efficacy, and potential implications for optimizing treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/all.70197","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:52:13Z","timestamp":1766487133000},"page":"1039-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role of Biologics in Reducing Mucous Plug Burden in Asthma"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-0167","authenticated-orcid":false,"given":"Remo","family":"Poto","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II  Naples Italy"},{"name":"Istituti Clinici Scientifici ICS Maugeri \u2013 S.P.A., Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Scientifico di Telese Terme  Telese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-8266","authenticated-orcid":false,"given":"Rory","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7367","authenticated-orcid":false,"given":"Corrado","family":"Pelaia","sequence":"additional","affiliation":[{"name":"Pneumology, Department of Medical and Surgical Sciences University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-2557","authenticated-orcid":false,"given":"G. 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