{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:33:05Z","timestamp":1787157185548,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic diseases\u2014including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma\u2014are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected. These conditions frequently coexist and share common genetic, environmental, dietary, and microbial risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature review was conducted, and a multidisciplinary Task Force of the German Society for Pediatric Allergology and Environmental Medicine (GPA) and the German Society for Allergology and Clinical Immunology (DGAKI) developed consensus\u2010based algorithms for early risk assessment and recognition of allergies in children in already existing preventive medical check\u2010ups. The approach emphasizes stepwise risk assessment, including family history, environmental exposures, and early clinical signs such as recurrent wheezing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For children identified as at risk for or with early clinical signs of atopy, targeted diagnostic steps are recommended that follow the national\/international guidelines for the management of the suspected atopic disease. This may include general and specific recommendations for nutrition, measurement of specific sensitization and selected biomarkers, if indicated and recommended by the guidelines. Routine allergy testing in asymptomatic children is not recommended. The algorithms are designed to be embedded into routine pediatric check\u2010ups, enabling systematic and early identification of children at increased risk or with early clinical signs of atopic diseases. Early recognition and management can reduce disease severity, improve quality of life, and decrease healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Structured programs for early risk assessment and recognition of allergies in children are currently lacking but can provide substantial clinical and economic benefits. Integration into routine pediatric preventive examinations, supported by standardization, interdisciplinary collaboration, and sustainable funding, offers a promising strategy to improve long\u2010term outcomes for affected children and their families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70224","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:40:36Z","timestamp":1769406036000},"page":"1971-1984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms"],"prefix":"10.1111","volume":"81","author":[{"given":"E.","family":"Hamelmann","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Center Bethel, University Hospital OWL University Bielefeld  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-8873","authenticated-orcid":false,"given":"B.","family":"Schaub","sequence":"additional","affiliation":[{"name":"Pediatric Allergology, Department of Pediatrics, Dr. Von Hauner Children's Hospital University Hospital  Munich Germany"},{"name":"Member of German Center for Lung Research\u2014DZL, LMU  Munich Germany"},{"name":"Member of German Center for Child and Adolescent Health\u2014DZKJ, LMU  Munich Germany"},{"name":"Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Member of German Center for Child and Adolescent Health (DZKJ)\u2010Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bl\u00fcmchen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pneumology, Allergology, Gastroenterology and Infectious Diseases Goethe University  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gerstlauer","sequence":"additional","affiliation":[{"name":"Paediatric and Adolescent Medicine, Department of Paediatric Pneumology and Allergology University Medical Center Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Kopp","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lange","sequence":"additional","affiliation":[{"name":"GFO Kliniken Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-4265","authenticated-orcid":false,"given":"S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Member of German Center for Child and Adolescent Health (DZKJ)\u2010Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maison","sequence":"additional","affiliation":[{"name":"Pediatric Allergology, Department of Pediatrics, Dr. Von Hauner Children's Hospital University Hospital  Munich Germany"},{"name":"Member of German Center for Lung Research\u2014DZL, LMU  Munich Germany"},{"name":"Member of German Center for Child and Adolescent Health\u2014DZKJ, LMU  Munich Germany"},{"name":"Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich  Munich Germany"},{"name":"Institute of Asthma\u2010 and Allergy Prevention (IAP), Helmholtz Zentrum Munich German Research Center for Environmental Health (GmbH)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ott","sequence":"additional","affiliation":[{"name":"Section of Pediatric Dermatology, Munich University Center for Children With Medical and Developmental Complexity Ludwig\u2010Maximilians\u2010University Hospital  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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