{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:28:41Z","timestamp":1792625321158,"version":"4.5.0"},"reference-count":165,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/PAT3959823(OG)"],"award-info":[{"award-number":["10.55776\/PAT3959823(OG)"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32953andI4437(BB)"],"award-info":[{"award-number":["P32953andI4437(BB)"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P36664(KMS)"],"award-info":[{"award-number":["P36664(KMS)"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/KLP4891723(JED)"],"award-info":[{"award-number":["10.55776\/KLP4891723(JED)"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC22167\u2010390884018(RAM)"],"award-info":[{"award-number":["EXC22167\u2010390884018(RAM)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MA2273\/16\u20101(CCU)"],"award-info":[{"award-number":["MA2273\/16\u20101(CCU)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE\u2010mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma. B cells play a central role by producing allergen\u2010specific IgE, presenting antigens, releasing cytokines, and forming memory B cells (MBCs). Their differentiation into IgE\u2010secreting plasma cells (PCs) mainly relies on T cell help, germinal center (GC) reactions, and\/or extrafollicular responses and class switch recombination (CSR), which makes them important therapeutic targets. The nasal mucosa, as the first point of contact for allergens, acts both as a barrier and as an immunological site. In AR, IL\u201013\u2010driven goblet cell hyperplasia and overproduction of mucus compromise the integrity of the barrier. Although the nasal microbiome can influence the immune response, its role in atopy remains unclear. Local B cell activity, including extrafollicular IgE production and ectopic GCs, enhances mucosal immunity. Epithelial cells detect allergens via pattern recognition receptors (PRRs) and release alarmins (IL\u201025, IL\u201033, TSLP), which can trigger type 2 inflammation. Proteases from allergens such as house dust mites (HDM) disrupt epithelial junctions, while pollutants, smoke, microplastics, and allergen\u2010derived metabolites further modulate immune activation. Allergens are transported to the lymph nodes by the passive flow to follicular dendritic cells (FDCs) or by active uptake by interferon regulatory factor (IRF) 4\u2010dependent conventional type 2 DCs, which activate T follicular helper (TFH) cells to drive IgE responses. Advanced lymphoid organoids that mimic the microenvironment of GCs offer promising models for the study of allergic sensitization but require improved standardization.<\/jats:p>","DOI":"10.1111\/all.70229","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:21:22Z","timestamp":1769235682000},"page":"1985-2000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract\u2014the B Cell Side"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-2556","authenticated-orcid":false,"given":"Ola","family":"Grimsholm","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-2601","authenticated-orcid":false,"given":"Mohammed","family":"Zghaebi","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab, Department of Otorhinolaryngology, Head and Neck Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7908-2305","authenticated-orcid":false,"given":"Bita","family":"Hambrecht","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-0244","authenticated-orcid":false,"given":"Tanja","family":"Kalic","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"},{"name":"Department of Dermatology University Hospital St. P\u00f6lten, Karl Landsteiner University of Health Sciences  St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-6217","authenticated-orcid":false,"given":"Christopher C.","family":"Udoye","sequence":"additional","affiliation":[{"name":"Institute for Systemic Inflammation Research University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-7693","authenticated-orcid":false,"given":"Rudolf","family":"Manz","sequence":"additional","affiliation":[{"name":"Institute for Systemic Inflammation Research University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-7985","authenticated-orcid":false,"given":"Barbara","family":"Bohle","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-0322","authenticated-orcid":false,"given":"Katarzyna M.","family":"Sitnik","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-1607","authenticated-orcid":false,"given":"Julia","family":"Eckl\u2010Dorna","sequence":"additional","affiliation":[{"name":"Vienna Airway Lab, Department of Otorhinolaryngology, Head and Neck Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-8689","authenticated-orcid":false,"given":"Heimo","family":"Breiteneder","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-025-09053-2"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16620"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.167042"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2023.04.008"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.640"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15483"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0347-y"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526604"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.001"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/82717"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi0944"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi0673"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12937"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.036"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.09.002"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0248-y"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.05.011"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0449-8"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.04.021"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419061.2010.551682"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1525928"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.040"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.01.007"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13603-6"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.70082"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1500"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-2112OC"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01261-2"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03464.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01592-2019"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4050"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01301-x"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.771136"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S472632"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.70089"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00337.x"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.5861"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.019"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42625-4"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00410-w"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07748-8"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2421724122"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100349"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2023.02.008"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102490"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124606"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12878"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00733"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13788"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13940"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07548"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.036"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1393819"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.692049"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1209097"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01255-6"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.06.006"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801430-1.00004-4"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01011-2"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-020-00341-y"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14861"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-023-01100-2"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1062316"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137374"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.04.029"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16226"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16448"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1348272"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11030683"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01014-8"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/jox14040086"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2019.0011"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.79430"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2021.01928"},{"issue":"8","key":"e_1_2_14_77_1","first-page":"359","article-title":"Protein A Superantigen: Structure, Engineering and Molecular Basis of Antibody Recognition","volume":"32","author":"Mazigi O.","year":"2019","journal-title":"Protein Engineering, Design & Selection"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1242702"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13608"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15240"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27022-y"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1226-4"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15762"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121613"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94673-9"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13462"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.887672"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1508786"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178434"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125703"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-229567"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.014"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.02.011"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1425"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.11.013"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3689"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1494"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-061020-053707"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01079-5"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.019"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI1219-425R"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam9169"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231282"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.029"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2309"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.177230"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646518"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.03.001"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190472"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1286638"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15542"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf9561"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16473"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00567-y"},{"key":"e_1_2_14_115_1","first-page":"1","article-title":"Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses","volume":"388","author":"He J. S.","year":"2015","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.009"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131539"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21238"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00402"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.12.006"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adm8964"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.04.001"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13421"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.015"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220964"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.10.011"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.10.006"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav8402"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02745.x"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.881655"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.03.015"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.01.005"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14073"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15746"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12607"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12236"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.022"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12835"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.08.002"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03636-8"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.039"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111941"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw6433"},{"key":"e_1_2_14_144_1","doi-asserted-by":"crossref","unstructured":"C.Udoye C.Rau A.\u2010K.Clauder et\u00a0al. \u201cDivergent IgE to IgG Hypermutation Is Associated With Allergic Hypothermia in Mice \u201d(2025) https:\/\/wiley.authorea.com\/users\/955882\/articles\/1324896\u2010divergent\u2010ige\u2010to\u2010igg\u2010hypermutation\u2010is\u2010associated\u2010with\u2010allergic\u2010hypothermia\u2010in\u2010mice.","DOI":"10.22541\/au.175510288.82248699\/v1"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100988"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.015"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14724"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.007"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14763"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16220"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.06.005"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2006.00303.x"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1458"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01145-0"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.019"},{"key":"e_1_2_14_156_1","doi-asserted-by":"crossref","unstructured":"A.\u2010S. S.Teufel A. W.Eiken Z. W.Wagoner et\u00a0al. \u201cLymphoid\u2010Tissue\u2010On\u2010Chip Recapitulates Human Antibody Responses In\u00a0Vitro \u201d(2025).","DOI":"10.1101\/2025.01.14.632762"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20240289"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-02037-1"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-95031-9"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-7"},{"key":"e_1_2_14_161_1","unstructured":"\u201cMultiparametric Optimization of Human Primary B\u2010Cell Cultures Using Design of Experiments \u201d(2025) https:\/\/doi.org\/10.1101\/2025.01.16.633474v1."},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100332"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.85"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2016-0075"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731"},{"issue":"5","key":"e_1_2_14_166_1","first-page":"433","article-title":"Differences in Innate Immune Response Between Man and Mouse","volume":"34","author":"Zschaler J.","year":"2014","journal-title":"Critical Reviews in Immunology"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:22:11Z","timestamp":1787156531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":165,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/all.70229"],"URL":"https:\/\/doi.org\/10.1111\/all.70229","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"2025-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}