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CD207 (Langerin)\n                      <jats:sup>+<\/jats:sup>\n                      dendritic cells (DCs) are localized at the airway epithelial interface. However, whether these cells respond to epithelial\u2010derived cytokines and contribute to the Th2 immune response in asthma remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single\u2010cell RNA\u2010seq from healthy human lungs was analyzed to define the transcriptomic features of CD207\n                      <jats:sup>+<\/jats:sup>\n                      DCs. Their function was validated in a house dust mite (HDM)\u2010induced asthma model using\n                      <jats:italic>Cd207<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. Flow cytometry was performed on lung and mediastinal lymph nodes. DC\u2013T cell co\u2010cultures were used to assess Th2 polarization. Epithelial\u2013DC interactions were evaluated using transwell co\u2010culture with ALI\u2010differentiated tracheal epithelial cells. Clinical relevance was examined in airway samples from asthma patients in the U\u2010BIOPRED cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD207\n                      <jats:sup>+<\/jats:sup>\n                      DCs were enriched in intraepithelial compartments and exhibited increased MHC\u2010II and Claudin\u20101 expression. In asthma, their abundance correlated with T2 signatures and Th2 markers (CRTH2, ST2). CD207 deletion reduced HDM uptake, Th2 cytokines, airway inflammation, and Th2 differentiation. IL\u201025 induced CD207\n                      <jats:sup>+<\/jats:sup>\n                      DCs and enhanced their Th2\u2010polarizing capacity in\u00a0vitro. An IL\u201025\u2013CD207 co\u2010expression score correlated with IL\u20104\/IL\u20105\/IL\u201013 levels and was higher in steroid\u2010na\u00efve patients with severe asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study identifies CD207\n                      <jats:sup>+<\/jats:sup>\n                      DCs as epithelial\u2010associated antigen\u2010presenting cells that bridge IL\u201025 signaling and Th2 polarization in allergic asthma. Targeting the IL\u201025\u2013CD207 axis may offer therapeutic opportunities for T2\u2010high asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70244","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:51:38Z","timestamp":1770025898000},"page":"1522-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epithelial\u2010Associated\n                    <scp>CD207<\/scp>\n                    <sup>+<\/sup>\n                    <scp>DCs<\/scp>\n                    Link Allergen Sensing and\n                    <scp>IL<\/scp>\n                    \u201025\u2010Driven Th2 Inflammation in Asthma"],"prefix":"10.1111","volume":"81","author":[{"given":"Heng","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanjing Medical University  Nanjing 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