{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:26:16Z","timestamp":1791095176083,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our previous study demonstrated that laundry detergents induce group 2 innate lymphoid cell\u2010driven eosinophilic airway inflammation by disrupting airway epithelial barriers and promoting IL\u201033 release, and that detergent residues are present in nearly all household dust. However, their impact on allergen\u2010induced airway inflammation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6 background mice were intranasally primed four times with ovalbumin (OVA) or house dust mite (HDM) allergens in the presence or absence of a commercial laundry detergent. Following priming, mice were challenged with the same antigen for 3 consecutive days and sacrificed the day after the final challenge. Bronchoalveolar lavage fluid (BALF) and sera were analyzed by ELISA. Lungs were evaluated histologically and analyzed by qPCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice intranasally primed with antigen in the presence of detergent exhibited eosinophilic airway inflammation upon antigen challenge, accompanied by increased IL\u20105 and IL\u201013 levels in the BALF. Intranasal administration of detergent and antigen also stimulated antigen\u2010specific IgE production. These detergent\u2010 and allergen\u2010induced type 2 responses were significantly suppressed in\n                      <jats:italic>Il33<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>Il13<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice. Administration of an anti\u2010IL\u20104 receptor \u03b1 chain antibody during the challenge phase reduced eosinophil counts in the BALF and antigen\u2010specific IgE levels in the serum. By contrast, anti\u2010IL\u201033 antibody treatment during the challenge phase did not affect eosinophilic airway inflammation or antigen\u2010specific IgE production.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laundry detergents promote sensitization to co\u2010inhaled allergens and exacerbate eosinophilic airway inflammation and antigen\u2010specific IgE responses via IL\u201033 and IL\u201013. These findings suggest that detergents can act as adjuvants that facilitate airway sensitization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70245","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:50:46Z","timestamp":1770281446000},"page":"1111-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Laundry Detergents Enhance Sensitization to Co\u2010Inhaled Allergens and Exacerbate Airway Inflammation in Mice"],"prefix":"10.1111","volume":"81","author":[{"given":"Naoko","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tamari","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Nakazaki","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatrics Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatrics The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-5501","authenticated-orcid":false,"given":"Kenichiro","family":"Motomura","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Division of Immuno\u2010Biomedical Research, Integrated Center for Women's Health National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne Johanna Maria","family":"de Bruijn","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Computer Science Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Arae","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Department of Immunology, Faculty of Health Sciences Kyorin University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-2551","authenticated-orcid":false,"given":"Terufumi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ikutani","sequence":"additional","affiliation":[{"name":"Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Sudo","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Research Center Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Kage","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Nakae","sequence":"additional","affiliation":[{"name":"Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-6927","authenticated-orcid":false,"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-019X","authenticated-orcid":false,"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich  Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-8322","authenticated-orcid":false,"given":"Hideaki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development  Tokyo Japan"},{"name":"Allergy Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14582"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00087506"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.11.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16318"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14181"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15057"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14091"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12279"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.02.036"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.032094"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.833217"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.190819"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16456"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15762"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03264-5"},{"issue":"3","key":"e_1_2_10_21_1","first-page":"167","article-title":"Bronchial Asthma due to Sensitization to Chloramine T","volume":"2","author":"Blasco A.","year":"1992","journal-title":"Journal of Investigational Allergology & Clinical Immunology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.12.840"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2003.011288"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.03.025"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6786-5_10"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.9906137"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15678"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.003"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268651"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15457"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804093"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804092"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00322-2"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0430OC"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.026"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041033"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.021"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000029"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.011"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.05.026"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.050"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15653"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024257"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.08.039"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01799-5"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0144-2022"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:50:49Z","timestamp":1775040649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/all.70245"],"URL":"https:\/\/doi.org\/10.1111\/all.70245","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}