{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:11:22Z","timestamp":1771049482463,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007305","name":"Maternal and Child Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Food allergies in children represent a growing clinical and public health concern worldwide, yet their causes remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of circulating IgG antibodies to food allergens and viral antigens at birth and during early childhood in the development of food allergies, using data from a prospective birth cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 458 children composed of 80 with food allergies, 151 with food sensitization, and 227 who were non\u2010allergic and non\u2010sensitized to these food allergens and had no other allergic diseases (asthma, atopic dermatitis, and allergic rhinitis). Phage ImmunoPrecipitation Sequencing (PhIP\u2010Seq) was used to profile the IgG antibody reactome against thousands of environmental antigens (including allergens and viruses) in matched cord blood and childhood plasma samples from these children. We then investigated whether IgG profiles were associated with allergies to egg, milk, and peanut.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Children with food allergies had a significantly elevated diversity of IgG reactivity to thousands of allergen peptides in early childhood compared to non\u2010allergic controls. No such associations were found in cord blood at birth. We identified that peanut\u2010allergic children have higher IgG reactivity to 24 peanut peptides, and egg\u2010allergic children had higher IgG reactivity to 17 egg peptides compared to non\u2010allergic controls. Additionally, patterns of shared IgG reactivity to wheat peptides were observed across different food allergy groups in early childhood. Notably, milk\u2010allergic children exhibited lower magnitudes of IgG reactivities to eight milk peptides in cord blood and reduced IgG reactivities to enteroviral peptides during childhood (all FDR &lt;\u20090.05), relative to non\u2010allergic controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that unbiased IgG reactome profiling in a prospective birth cohort provides new insights into early life immune regulation and its influence on childhood allergic phenotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70246","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:31:26Z","timestamp":1771047086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diverse Food Allergen\n                    <scp>IgG<\/scp>\n                    Reactivities Are Associated With Food Allergies in the Boston Birth Cohort"],"prefix":"10.1111","author":[{"given":"Julia W.","family":"Angkeow","sequence":"first","affiliation":[{"name":"Institute for Cell Engineering, Division of Immunology, Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-1918","authenticated-orcid":false,"given":"Xiumei","family":"Hong","sequence":"additional","affiliation":[{"name":"Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjusha","family":"Thakar","sequence":"additional","affiliation":[{"name":"Institute for Cell Engineering, Division of Immunology, Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-5546","authenticated-orcid":false,"given":"Pamela A.","family":"Frischmeyer\u2010Guerrerio","sequence":"additional","affiliation":[{"name":"Food Allergy Research Section, NIAID\/DIR  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health Johns Hopkins University Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Department of Pediatrics Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-196X","authenticated-orcid":false,"given":"H. Benjamin","family":"Larman","sequence":"additional","affiliation":[{"name":"Institute for Cell Engineering, Division of Immunology, Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-1235","article-title":"The Public Health Impact of Parent\u2010Reported Childhood Food Allergies in the United States","volume":"142","author":"Gupta R. S.","year":"2018","journal-title":"Pediatrics"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jaci.2014.05.042","article-title":"Oral Immunotherapy Induces IgG Antibodies That Act via Fc\u03b3RIIb to Suppress IgE\u2010Mediated Hypersensitivity","volume":"134","author":"Burton O. 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