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Diagnosis is challenging, highlighting the need for new approaches enhancing in\u00a0vitro sensitivity and specificity. Engineered nanostructures can mimic immunological recognition of hapten\u2010carrier conjugates, offering a strategy to improve diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dendrimeric Antigens (DeAns), with controlled size (1st\u20135th generation) and multivalent AX determinants (8\u2013128\u2009units, respectively), were synthesized for in\u00a0vitro immunological evaluation. In\u00a0vitro IgE recognition was studied by competitive radio\u2010immunoassay. Allergenic activity was evaluated in mouse bone marrow\u2010derived mast cells (MC) sensitized with mouse anti\u2010AX IgE monoclonal antibody and humanized RBL\u20102H3 (huRBL\u20102H3) and LUVA cells sensitized with sera from \u03b2\u2010lactam\u2010allergic subjects and tolerant controls, measuring degranulation in response to DeAns stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five different DeAns were obtained as pure compounds. All DeAns were recognized by AX\u2010sIgE. A clear size\u2010dependent activation pattern was observed in the three cell models: lower\u2010generation (1st\u20132nd) DeAns failed to induce degranulation, whereas DeAns of bigger size (3rd\u20135th generation) triggered significant, dose\u2010dependent activation. Notably, no activation was observed in tolerants and unsensitized cells or with blank dendrimers. In patient\u2010sera assays, the passive MC activation test (pMAT) with DeAns provided complete diagnostic discrimination, with activation restricted to AX\u2010allergic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DeAns are effective platforms for investigating effector cell activation in AX allergy. By fine\u2010tuning structural attributes\u2014size and multivalence\u2014we reveal the promising utility of DeAns in pMAT that leverage commercial cell lines and patient sera. This approach could address key limitations of \u03b2\u2010lactam allergy diagnostics, enabling more reliable and standardized in\u00a0vitro testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70250","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:19:37Z","timestamp":1770855577000},"page":"2898-2909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-8895","authenticated-orcid":false,"given":"Amene Tesfaye","family":"Ayane","sequence":"first","affiliation":[{"name":"Allergy Research Group Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2014IBIMA Plataforma BIONAND  M\u00e1laga Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-9492","authenticated-orcid":false,"given":"Maria","family":"Salas","sequence":"additional","affiliation":[{"name":"Allergy Research Group Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2014IBIMA Plataforma BIONAND  M\u00e1laga Spain"},{"name":"Allergy Unit Hospital Regional Universitario de M\u00e1laga\u2010HRUM  M\u00e1laga Spain"},{"name":"Departamento de Medicina y Dermatolog\u00eda Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9288-9438","authenticated-orcid":false,"given":"Sara","family":"Benede","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CIAL), CSIC\u2010UAM  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-0642","authenticated-orcid":false,"given":"Maria J.","family":"Rodriguez\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Research (CIBM) University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (ibs. 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