{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:20:44Z","timestamp":1793838044712,"version":"4.6.1"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Artemisia desertorum<\/jats:italic>\n                      (desert mugwort) is widely planted in the Mu Us Desert of northwestern China for windbreak and sand fixation, but extensive cultivation has unexpectedly increased pollen\u2010induced allergies. This study aims to perform allergen molecular diagnosis and evaluate its utility in characterizing immunoglobulin E (IgE) sensitization profiles linked to allergic phenotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and thirty\u2010five\n                      <jats:italic>Artemisia<\/jats:italic>\n                      \u2010allergic patients from three regions differing in the\n                      <jats:italic>Artemisia<\/jats:italic>\n                      pollen exposure were examined. Eleven allergens were either purified naturally or recombinantly for IgE quantification using the ImmunoCAP assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At least one allergen response was detected in 134 patients. Major allergens included Art d 1 (85.2%), Art d 2 (62.2%), Art d 3 (88.9%), Art d 7 (82.2%), and Art d 9 (54.1%). Patients from the high desert mugwort exposure region exhibited elevated serum\u2010specific immunoglobulin E (sIgE) levels, increased sensitization to mugwort extract and allergen molecules, broader polysensitization, and higher asthma prevalence. Number of sensitized allergens and sIgE levels to mugwort extract and Art d 3 were independently associated with asthma in multivariable analysis. A predictive model was developed for asthma prediction with an AUC of 0.832.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      High environmental exposure to\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. desertorum<\/jats:italic>\n                      <\/jats:styled-content>\n                      pollen increases pollen allergy prevalence and asthma risk in Mu Us Desert residents. Molecular allergy diagnostics with a comprehensive\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. desertorum<\/jats:italic>\n                      <\/jats:styled-content>\n                      allergen panel enhanced diagnostic precision, supported disease severity prediction, and provided critical insights for improved clinical management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70253","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:34:38Z","timestamp":1770788078000},"page":"1536-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Allergen Diagnosis Reveals That Asthma Risk Is Linked to Desert Mugwort Pollen Exposure"],"prefix":"10.1111","volume":"81","author":[{"given":"Lan","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Immunology and Allergy Research Center, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Department of Allergy Beijing Shijitan Hospital, Capital Medical University  Beijing China"},{"name":"College of Agriculture and Biotechnology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-3155","authenticated-orcid":false,"given":"Wanyi","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Allergy Research Center, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Yang","sequence":"additional","affiliation":[{"name":"Ordos Second People's Hospital  Ordos China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Li","sequence":"additional","affiliation":[{"name":"Ordos Second People's Hospital  Ordos China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Hangzhou Aileji Biotech Ltd  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Hangzhou Zheda Dixun Biological Gene Engineering Co. 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