{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:39:03Z","timestamp":1787791143812,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergen immunotherapy is the only disease\u2010modifying treatment for IgE\u2010mediated diseases for patients 5\u2009years and over. The question is often asked why children receive the same doses as adults. There is not a single dose\u2010finding study including children and\/or adolescents. Moreover, randomized controlled trials that include all age groups but report effects separately are rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This randomized trial investigated the safety and tolerability of an accelerated dose escalation schedule (One\u2010Strength group) compared to the standard regimen (Standard group) when using a birch pollen SCIT allergoid in patients aged 5\u201365\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 201 patients were randomized to the two regimens: 87 adults, 52 adolescents, 62 children. Three hundred eighty\u2010two treatment\u2010related adverse drug reactions (ADRs) occurred in 81 patients (40.5%). A higher proportion of patients in the One\u2010Strength group (48.5%) experienced at least one ADR compared to those in the Standard group (32.0%). The majority of ADRs were local (93.3%), and the majority were of mild intensity (95.8%). 3 patients in the One\u2010Strength and 1 patient in the Standard group developed a total of 9 systemic ADRs, which all were classified as WAO grade 1 or 2 and most of mild intensity. No event of WAO grade 3 or higher was reported. No serious ADR occurred. Overall, tolerability was assessed as \u201cvery good\u201d or \u201cgood\u201d by more than 96% of investigators and patients. Safety and tolerability were comparable in the three age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Birch pollen SCIT was safe and well\u2010tolerated when administered using a One\u2010Strength dose\u2010escalation regimen in patients aged 5\u201365\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70265","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:10:49Z","timestamp":1772957449000},"page":"2079-2088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A One\u2010Strength Dose Escalation Regimen for Birch Pollen Subcutaneous Immunotherapy Is Safe and Tolerable in Children, Adolescents, and Adults"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-9379","authenticated-orcid":false,"given":"Marek","family":"Jutel","sequence":"first","affiliation":[{"name":"All\u2010MED Medical Research Institute  Wroc\u0142aw Poland"},{"name":"Department of Clinical Immunology Wroc\u0142aw Medical University  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-0192","authenticated-orcid":false,"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-0664","authenticated-orcid":false,"given":"Michael","family":"Gerstlauer","sequence":"additional","affiliation":[{"name":"Pediatric and Adolescent Medicine University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Troyke","sequence":"additional","affiliation":[{"name":"Allergopharma GmbH &amp; Co. KG  Reinbek Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Duwensee","sequence":"additional","affiliation":[{"name":"Allergopharma GmbH &amp; Co. KG  Reinbek Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-8368","authenticated-orcid":false,"given":"Christian","family":"Vogelberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70273-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13758"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1658-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02089.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02331E"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13317"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13331"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1o3532.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03521.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00387.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S242957"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13598"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16363"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.014"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01068.x"},{"key":"e_1_2_12_20_1","unstructured":"\u201cGlobal Initiative for Asthma: Global Strategy for Asthma Management and Prevention 2021 \u201dwww.ginasthma.org."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.060"},{"issue":"140","key":"e_1_2_12_22_1","first-page":"5","article-title":"A Technique for the Measurement of Attitudes","volume":"22","author":"Likert R.","year":"1932","journal-title":"Archives of Psychology"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503684"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512561"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16370"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.06.036"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.11.027"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0143"},{"issue":"4","key":"e_1_2_12_29_1","first-page":"4","article-title":"An Accelerated Dose Escalation With a Grass Pollen Allergoid Is Safe and Well\u2010Tolerated: A Randomized Open Label Phase II Trial","volume":"6","author":"Chaker A. M.","year":"2016","journal-title":"Clinical and Translational Allergy"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0561"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464103"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343026"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15506"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-020-00155-1"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12245"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1243632"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-014-0037-6"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7328469"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:22:32Z","timestamp":1787156552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/all.70265"],"URL":"https:\/\/doi.org\/10.1111\/all.70265","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"2025-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}