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Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research. Nevertheless, monoclonal anti\u2010IgE therapy with omalizumab has transformed allergy treatment and proven to be safe and effective in various allergic indications. A remaining limitation of omalizumab is its high cost and requirement for repeated dosing, which limits accessibility. Vaccination against IgE theoretically offers a promising, cost\u2010effective alternative, but long\u2010standing safety concerns have slowed its development. Here, we review emerging concepts in IgE biology and therapeutic IgE neutralization. Recent research demonstrates that vaccine\u2010induced anti\u2010IgE antibodies can selectively neutralize free IgE while sparing Fc\u03b5RI\u2010bound IgE, thereby avoiding effector cell activation. This mechanism mirrors the behavior of natural anti\u2010IgE autoantibodies, which may regulate physiological IgE homeostasis. Together, these novel insights indicate that anti\u2010IgE vaccination is safe, biologically grounded, and a compelling strategy for the long\u2010term control of IgE\u2010mediated allergic disease.<\/jats:p>","DOI":"10.1111\/all.70287","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:20:47Z","timestamp":1773289247000},"page":"2001-2013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case for Anti\u2010\n                    <scp>IgE<\/scp>\n                    Vaccination"],"prefix":"10.1111","volume":"81","author":[{"given":"Paul","family":"Engeroff","sequence":"first","affiliation":[{"name":"Department of BioMedical Research (DBMR) University of Bern  Bern Switzerland"},{"name":"Department for Rheumatology and Immunology University Hospital of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Gharailoo","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research (DBMR) University of Bern  Bern Switzerland"},{"name":"Department for Rheumatology and Immunology University Hospital of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research (DBMR) University of Bern  Bern Switzerland"},{"name":"Department for Rheumatology and Immunology University Hospital of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research (DBMR) University of Bern  Bern Switzerland"},{"name":"Department for Rheumatology and Immunology University Hospital of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1993.tb00687.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1181"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_8_5_1","volume-title":"IgE Antibodies: Generation and Function","author":"Lafaille J. 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