{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:16:53Z","timestamp":1791605813666,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013669","name":"Ionis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Donidalorsen is an antisense oligonucleotide designed to reduce plasma prekallikrein in patients with hereditary angioedema (HAE). The Switch cohort of the OASISplus study (NCT05392114) evaluated the long\u2010term safety and efficacy of donidalorsen in patients who switched from a long\u2010term prophylactic treatment (LTP) to donidalorsen with 1\u2010year outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled patients with HAE aged \u2265\u200912\u2009years previously on stable doses of an LTP (lanadelumab, berotralstat, C1 inhibitor). Patients directly switched from an LTP to donidalorsen 80\u2009mg administered subcutaneously once every 4\u2009weeks. Endpoints included incidence and severity of treatment\u2010emergent adverse events (TEAEs; primary endpoint), monthly HAE attack rate, Angioedema Quality of Life (AE\u2010QoL), and Angioedema Control Test (AECT) measured at baseline and Week 52.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010five patients enrolled, and 54 (83.1%) completed 1\u2009year. Eleven (16.9%) patients discontinued treatment during the first year, and one discontinued treatment after 1\u2009year. Donidalorsen reduced HAE attack rates from baseline on the prior LTP by 67.6% over 52\u2009weeks. Fifty\u2010six of 64 (87.5%) dosed patients experienced a TEAE; most reported mild to moderate events. The most common treatment\u2010related TEAEs were injection\u2010site erythema (10.9%) and injection\u2010site pruritus (10.9%). One patient had a serious adverse event that was not treatment\u2010related. AE\u2010QoL total score improved by 12.2 points (clinically meaningful \u2265\u20096 points) from baseline to Week 52, and 90.4% of patients had well\u2010controlled disease (AECT \u2265\u200910) at Week 52.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients who switched from another LTP, donidalorsen was well tolerated and improved long\u2010term HAE attack rates, quality of life, and disease control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70294","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:25:47Z","timestamp":1773476747000},"page":"2833-2842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Switching Long\u2010Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1\u2010Year\n                    <scp>OASISplus<\/scp>\n                    Results"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-1544","authenticated-orcid":false,"given":"Marc A.","family":"Riedl","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-1196","authenticated-orcid":false,"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine University of Cincinnati College of Medicine, Bernstein Clinical Research Center, LLC  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Allergy and Asthma Clinical Research, Inc.  Walnut Creek California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-4855","authenticated-orcid":false,"given":"Timothy","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pediatrics, MFM, and Biomedical Sciences Penn State University, Allergy, Asthma, and Immunology  Hershey Pennsylvania USA"},{"name":"Vinmec International Hospital, Times City  Hanoi Vietnam"},{"name":"VinUniversity  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Lumry","sequence":"additional","affiliation":[{"name":"Asthma and Allergy Research Associates  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. James","family":"Wedner","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Washington University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleena","family":"Banerji","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Gierer","sequence":"additional","affiliation":[{"name":"Division of Allergy, Clinical Immunology &amp; Rheumatology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Smith","sequence":"additional","affiliation":[{"name":"Allergy Associates of Utah  Sandy Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Manning","sequence":"additional","affiliation":[{"name":"Medical Research of Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Perego","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istituti Clinici Scientifici Maugeri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bordone","sequence":"additional","affiliation":[{"name":"Ionis  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Treadwell","sequence":"additional","affiliation":[{"name":"Ionis  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Ionis  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Ionis  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Yarlas","sequence":"additional","affiliation":[{"name":"Ionis  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-3723","authenticated-orcid":false,"given":"Danny M.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2402478"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2011.02751.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100627"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.02.018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010021\u201000537\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010021\u201001717\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100758"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.016"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15948"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010023\u201000795\u20102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010025\u201000511\u2010y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"E.Kutrieb D.Weycker M.Vera Llonch et\u00a0al. \u201cDrug Patterns Clinical Outcomes and Economic Costs Among Hereditary Angioedema Patients Initiating Long\u2010Term Prophylaxis \u201dPoster presented at: Amercian College of Allergy Asthma and Immunology; October 24\u201328 2024; Boston MA.","DOI":"10.1016\/j.anai.2024.08.106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2025.46.250029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","unstructured":"K. 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