{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:58:55Z","timestamp":1792609135014,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82025010"],"award-info":[{"award-number":["82025010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870698"],"award-info":[{"award-number":["81870698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471135"],"award-info":[{"award-number":["82471135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171108"],"award-info":[{"award-number":["82171108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory respiratory disease. Its eosinophilic subtype (ECRSwNP), characterized by pronounced type 2 inflammation, mucosal edema and stromal remodeling, presents particular therapeutic challenges. Emerging evidence suggests metabolic dysregulation may contribute to its pathogenesis, but the underlying mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Untargeted metabolomics was performed using plasma and nasal mucosa from mouse models of CRSwNP with type 2 inflammation; targeted metabolomics was applied to plasma from patients with CRSwNP and healthy controls. Murine models, primary cells derived from nasal polyps, and samples from patients who had received anti\u2010IL\u20104R\u03b1 monoclonal antibody were used to evaluate the role of 15(S)\u2010hydroxyeicosatetraenoic acid [15(S)\u2010HETE] in CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(1) Mechanistically: The arachidonate 15\u2010lipoxygenase (ALOX15)\u2010dependent metabolite 15(S)\u2010HETE, derived from arachidonic acid and induced by interleukin (IL)\u20104 and IL\u201013, correlated with CRSwNP severity. 15(S)\u2010HETE reduced transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) through peroxisome proliferator\u2010activated receptor gamma (PPAR\u2010\u03b3) activation, thereby impairing collagen production and exacerbating mucosal edema. (2) Therapeutically: In mouse models of CRSwNP, ALOX15 inhibition improved mucosal remodeling, reduced polyp size, and attenuated type 2 inflammation. Post hoc analysis of a clinical trial demonstrated that anti\u2010IL\u20104R\u03b1 treatment reversed this metabolic axis and improved mucosal remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work establishes the type 2 inflammation\u2013ALOX15\u201315(S)\u2010HETE\u2013PPAR\u2010\u03b3 axis as a key driver of impaired tissue remodeling in ECRSwNP through TGF\u2010\u03b21 suppression. These findings provide novel mechanistic insights into the inflammation\u2013metabolism\u2013remodeling interplay in CRSwNP and highlight promising therapeutic targets for this refractory condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70301","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:22:42Z","timestamp":1773768162000},"page":"1680-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Type 2 Inflammation\u2010Biased Arachidonic Acid Metabolite Regulates Mucosal Remodeling of Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1111","volume":"81","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-5135","authenticated-orcid":false,"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Department of Allergy Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University  Beijing China"},{"name":"Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.063"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020910"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13373"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21546"},{"issue":"29","key":"e_1_2_11_7_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. J.","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26604"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20193101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.08.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02556-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12472"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13223-015-0108-7","article-title":"Association Between Allergic Rhinitis and Metabolic Conditions: A Nationwide Survey in Korea","volume":"12","author":"Hwang I. C.","year":"2016","journal-title":"Allergy, Asthma, and Clinical Immunology: Official Journal of the Canadian Society of Allergy and Clinical Immunology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01954-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2021.106609"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.593976"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-020-00480-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22243"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01312-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2021.13.5.684"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4231"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22194"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12064"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102076"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.05.030"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.0000000000000123"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4717-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S461769"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1267194"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02014-8"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2025.2449709"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02880.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.12.010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4167"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022293"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00383.2004"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506111"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-022-00388-0"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1118-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97946"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13599"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2022.14.2.153"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.031"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000795"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.734733"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155884"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.0000000000000187"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.04.019"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00719"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151685"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238673"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082373"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02125-0"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60130-X"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2024.09.007"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190281"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21943"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000168111.11802.9c"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1356298"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.041"},{"issue":"1","key":"e_1_2_11_64_1","first-page":"29","article-title":"Epithelium and Stroma From Nasal Polyp Mucosa Exhibits Inverse Expression of TGF\u2010\u03b21 as Compared With Healthy Nasal Mucosa","volume":"42","author":"Balsalobre L.","year":"2013","journal-title":"Journal of Otolaryngology \u2010 Head & Neck Surgery = Le Journal D'oto\u2010Rhino\u2010Laryngologie et de Chirurgie Cervico\u2010Faciale"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09215.x"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6755407"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3159"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401533"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2006.05.002"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01231-1"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/34184"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139932"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1431-x"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14809"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.034"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2273502"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2020.106411"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102510"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:10:26Z","timestamp":1778155826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/all.70301"],"URL":"https:\/\/doi.org\/10.1111\/all.70301","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}