{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:19:37Z","timestamp":1790378377647,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011751","name":"Stiftelsen f\u00f6r Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009808","name":"V\u00e5rdal Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018861","name":"Konsul Th C Berghs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010234","name":"Astma- och Allergif\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity\u2010related asthma (OBA) is a distinct asthma phenotype, with increased severity. Adipokine release from excessive adipose tissue is suggested to be a key feature of OBA pathophysiology. However, it is unclear how the clinical characteristics of severe asthma associate with adipokine mediators. We examined systemic adipokine levels and evaluated relationships with disease severity, weight, sex, and steroid treatment in asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multiplex immunoassay for nine adipokines with proposed involvement in obesity\u2010related inflammation (adiponectin, adipsin, BAFF, chemerin, FGF\u201021, leptin, lipocalin\u20102\/NGAL, osteonectin and resistin) was designed. Plasma adipokines were measured in 127 patients with mild\u2010to\u2010moderate asthma (MMA) or severe asthma (SA) from the European BIOAIR cohort at baseline and after a controlled 2\u2010week oral corticosteroid (OCS) intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Leptin and chemerin were significantly increased in patients with SA vs. MMA. Leptin, adiponectin, adipsin, and NGAL were affected by sex, whereas leptin and adipsin were strongly affected by weight. OCS increased leptin and adiponectin, decreased adipsin and BAFF, and did not affect osteonectin, resistin, or chemerin. No adipokines showed positive associations with exhaled NO, blood or sputum eosinophils, although certain correlations with serum CRP, blood, and sputum neutrophils were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, we observe variable relationships between the nine adipokines, obesity and asthma severity. There were no relationships between adipokine levels and type\u20102 airway inflammation, yet associations with systemic neutrophilic inflammation were seen. Although one adipokine, chemerin, was independently associated with asthma severity, deciphering the role of adipokines in OBA is complex due to the influence of sex, BMI, and OCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70318","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:28:39Z","timestamp":1775273319000},"page":"3206-3220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adipokines in Obese Asthma: A Complex Relationship Influenced More by Sex, Weight, and Oral Steroid Treatment Than Disease Severity"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-4052","authenticated-orcid":false,"given":"Lars I.","family":"Andersson","sequence":"first","affiliation":[{"name":"Clinical Lung\u2010 and Allergy Research Unit, Department of Medicine Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Respiratory Medicine and Allergy Karolinska University Hospital Huddinge  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-7867","authenticated-orcid":false,"given":"Maciej","family":"Kupczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Asthma and Allergy Medical University of Lodz, University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-9034","authenticated-orcid":false,"given":"Barbro","family":"Dahl\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Lung\u2010 and Allergy Research Unit, Department of Medicine Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Respiratory Medicine and Allergy Karolinska University Hospital Huddinge  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-907X","authenticated-orcid":false,"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-6012","authenticated-orcid":false,"given":"Mina","family":"Gaga","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Dept and Asthma Centre, Athens Chest Hospital \u201cSotiria\u201d, University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-2377","authenticated-orcid":false,"given":"Nikos M.","family":"Siafakas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Medical School, University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-4500","authenticated-orcid":false,"given":"Alberto","family":"Papi","sequence":"additional","affiliation":[{"name":"Division of Internal and Cardiorespiratory Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-1964","authenticated-orcid":false,"given":"Bianca","family":"Beghe","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-9444","authenticated-orcid":false,"given":"Guy","family":"Joos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics Ghent University  Ghent Belgium"},{"name":"Department of Respiratory Medicine Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-1401","authenticated-orcid":false,"given":"Klaus F.","family":"Rabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Christian Albrecht's University Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-3574","authenticated-orcid":false,"given":"Elisabeth H.","family":"Bel","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-9200","authenticated-orcid":false,"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-0917","authenticated-orcid":false,"given":"Pascal","family":"Chanez","sequence":"additional","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-745X","authenticated-orcid":false,"given":"Mark","family":"Gjomarkaj","sequence":"additional","affiliation":[{"name":"Institute of Translational Pharmacology, Italian National Research Council  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-7927","authenticated-orcid":false,"given":"Peter H.","family":"Howarth","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Respiratory Biologics, Specialty Medicine, GSK  London UK"},{"name":"NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Clinical and Experimental Sciences, Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6651-259X","authenticated-orcid":false,"given":"Ewa","family":"Ni\u017cankowska\u2010Mogilnicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6354-3220","authenticated-orcid":false,"given":"Roelinde","family":"Middelveld","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-4002","authenticated-orcid":false,"given":"Sven\u2010Erik","family":"Dahl\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Lung\u2010 and Allergy Research Unit, Department of Medicine Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Respiratory Medicine and Allergy Karolinska University Hospital Huddinge  Stockholm Sweden"},{"name":"Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-2690","authenticated-orcid":false,"given":"Apostolos","family":"Bossios","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Allergy Karolinska University Hospital Huddinge  Stockholm Sweden"},{"name":"Karolinska Severe Asthma Centre Karolinska University Hospital Huddinge  Stockholm Sweden"},{"name":"Division for Lung and Airway Research Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"},{"name":"Lung Laboratory, Center for Molecular Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-8419","authenticated-orcid":false,"given":"Anna","family":"James","sequence":"additional","affiliation":[{"name":"Institute of Women's and Children's Health, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BIOAIR (Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease) and ChAMP consortia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.03.017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13123474"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.048"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1506331"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103570"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12419"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238990"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.11.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2010.550013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12221"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1244586"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.873699"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2023.2202976"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15570-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.3.024"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161161"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050634"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13020171"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13388"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12308"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010546"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2025.2505464"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-021-2350-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13653"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-8-12"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0760OC"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12445"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12179"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.652"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201815"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2017.1355378"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402996"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2017.1402151"},{"issue":"6","key":"e_1_2_11_36_1","article-title":"The Role of Chemerin in Neutrophil Activation and Diseases of the Lung","volume":"13","author":"Arndt P.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.02.004"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042222"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061321"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1031-3"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2018.07.008"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1741351"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01163-2019"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-015-0001-7"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.19213"},{"issue":"8","key":"e_1_2_11_47_1","first-page":"2542","article-title":"Glucocorticoid Regulation of Leptin Synthesis and Secretion in Humans: Elevated Plasma Leptin Levels in Cushing's Syndrome","volume":"82","author":"Masuzaki H.","year":"1997","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01099.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-008-0904-6"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.12.010"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12742"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcdt.2016.05.008"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2020.04.003"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2014.882934"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108344"},{"issue":"7","key":"e_1_2_11_56_1","article-title":"Assessment of Leptin Levels and Their Correlation With the Severity of Obstructive Sleep Apnea Syndrome: A Case\u2010Control Study","volume":"15","author":"Patial K.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108463"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2024.107917"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605251392717"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.70318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.70318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:20:40Z","timestamp":1789183240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.70318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/all.70318"],"URL":"https:\/\/doi.org\/10.1111\/all.70318","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}