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Despite its reported clinical utility, around 10%\u201320% of tested subjects fall into the category of basophil non\u2010releasers, meaning that their basophils fail to degranulate upon IgE\u2010mediated stimulation in\u00a0vitro. Several factors causing this non\u2010releaser status have been identified, but we currently lack a unified nomenclature to define such inconclusive BAT results and the practical steps to minimize such outcomes. In accordance with the STAndards for the Reporting of Diagnostic accuracy studies (STARD) statement, non\u2010releasers must be reported and considered in the calculation of clinical BAT performance metrics, as failure to do so significantly limits the broader implementation of BAT in routine practice. This review provides an overview of intrinsic and extrinsic factors responsible for the basophil non\u2010releaser phenotype in BAT. 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