{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:27:53Z","timestamp":1788996473716,"version":"build-2803163510"},"reference-count":114,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>AllergoOncology has emerged as an interdisciplinary field exploring the interaction between allergic diseases and cancer; however, the lack of stable in\u00a0vivo models has limited mechanistic investigations. This study aimed to establish an experimental animal model to explore the impact of systemic allergic responses on tumor progression and to provide preliminary insights into the regulatory role of allergy in cancer development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ovalbumin (OVA)\u2010induced systemic allergy tumor\u2010bearing mouse model (OVA\u2010TM) was established by OVA sensitization followed by subcutaneous implantation of CT26 colon cancer cells. Tumor growth, immune responses, and behavioral changes were systematically evaluated. Tumor immune microenvironment alterations were assessed using immunological and histological analyses. Transcriptomic profiling and mass spectrometry imaging (MSI) were integrated to investigate immune\u2010related metabolic alterations. Human tumor survival datasets were used to validate the prognostic relevance of differentially expressed genes (DEGs), and enrichment analyses of allergy\u2010 and cancer\u2010associated genes were performed using humanized databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OVA\u2010induced systemic allergy significantly suppressed tumor growth and promoted immune cell infiltration, particularly CD3\n                      <jats:sup>+<\/jats:sup>\n                      CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells. Transcriptomic analysis identified key DEGs, including\n                      <jats:italic>Aoc1, Apob, Apobec2<\/jats:italic>\n                      , and\n                      <jats:italic>Acta1<\/jats:italic>\n                      , whose expression correlated with overall survival in multiple cancer types. Integrated transcriptomics and pathway enrichment analysis revealed extensive functional reprogramming in OVA\u2010TM tumors, including activation of metabolic and immune\u2010related pathways. Consistent with these findings, spatial metabolomics analysis showed synergistic alterations in lipid and amino acid\u2010related metabolic pathways in both tumors and the spleen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study establishes a practical in\u00a0vivo model for AllergoOncology and demonstrates that systemic allergic responses can modulate tumor progression through immune activation, apoptosis, and inflammation\u2013metabolism axis reprogramming, providing a foundation for future mechanistic and therapeutic studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70331","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:48:28Z","timestamp":1775648908000},"page":"1763-1786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Food Allergy\u2010Induced Systemic Immune Alterations Affect Tumor Progression in a\n                    <scp>CT26<\/scp>\n                    Colon Adenocarcinoma Mouse Model"],"prefix":"10.1111","volume":"81","author":[{"given":"Xiaoyu","family":"Fan","sequence":"first","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7724-2647","authenticated-orcid":false,"given":"Shushu","family":"Guo","sequence":"additional","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeao","family":"Xu","sequence":"additional","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siman","family":"Sun","sequence":"additional","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"College of Pharmacy Shanxi University of Traditional Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-3717","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuming","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Key Laboratory for Safety Research and Evaluation of Innovative Drug National Medical Products Administration  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Jin","sequence":"additional","affiliation":[{"name":"New Drug Safety Evaluation Center Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Key Laboratory for Safety Research and Evaluation of Innovative Drug National Medical Products Administration  Beijing China"},{"name":"Beijing Union\u2010Genius Pharmaceutical Technology Development Co. 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