{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:20:36Z","timestamp":1794043236344,"version":"4.8.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2000773"],"award-info":[{"award-number":["2000773"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 memory B cells (Bmem) are the reservoir of pathogenic IgE in allergies. Allergen immunotherapy (AIT) can change the course of disease, but if it involves reprogramming of allergen\u2010reactive Bmem remains unknown. Here, we examine how AIT affects allergen\u2010specific Bmem in house dust mite (HDM) allergic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HDM allergic patients were longitudinally evaluated over 18\u2009months with or without sublingual HDM\u2010AIT. Visual analog scores, lung function tests, medication scores, serum IgE, and flowcytometric analysis of Der p 1 and Der p 2\u2010specific Type 2 Bmem were performed at t\u2009=\u20090, 4, 12, and 18\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients on HDM\u2010AIT showed clinical improvement over 18\u2009months with reduced intake of other medications and increases in specific serum IgE, IgG2, and IgG4. Allergen\u2010specific Bmem and the proportions of Type 2 Bmem therein became more abundant at 4 and 12\u2009months and showed upregulation of CD29 and IgG4. At 18\u2009months, the Type 2 Bmem proportions were reduced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A biphasic Bmem response with early phenotypic changes followed by loss of the Type 2 state was observed during 18\u2009months of AIT. As durable unresponsiveness takes 18\u2009months of AIT, deletion of Type 2 Bmem is likely an important step in disease attenuation. Interventions that expedite this outcome may be beneficial in driving remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70342","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:25:18Z","timestamp":1776482718000},"page":"2172-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biphasic Effects on Allergen\u2010Specific Type 2 Memory B Cells Over 18\u2009Months Sublingual Immunotherapy for House Dust Mite Allergy"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-4011","authenticated-orcid":false,"given":"Lin","family":"Hsin","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9001-9367","authenticated-orcid":false,"given":"Simone","family":"Reinwald","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Translational Medicine Monash University  Melbourne Victoria Australia"},{"name":"Allergy, Asthma and Clinical Immunology, Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-7936","authenticated-orcid":false,"given":"Anouk","family":"von Borstel","sequence":"additional","affiliation":[{"name":"Department of Immunology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-9989","authenticated-orcid":false,"given":"Pei Mun","family":"Aui","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Deckert","sequence":"additional","affiliation":[{"name":"Allergy, Asthma and Clinical Immunology, Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-7890","authenticated-orcid":false,"given":"P. 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