{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:54:42Z","timestamp":1791446082625,"version":"4.3.3"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031562","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de P\u00e9diatrie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017857","name":"Soci\u00e9t\u00e9 Francophone Nutrition Clinique et M\u00e9tabolisme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008765","name":"Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de Gastro-Ent\u00e9rologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gut microbiota and their metabolites play a key role in digestive dysimmunity and tolerance breakdown, leading to pathologies such as food protein\u2010induced enterocolitis syndrome (FPIES). This study aimed to compare both the gut and salivary microbiota over time between the allergic and tolerant patients and the matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Faecal and salivary samples were collected longitudinally from FPIES allergic patients on an elimination diet, and after their natural tolerance acquisition, and from matched controls (1:1 ratio). 16S rRNA gene sequencing and biostatistical analyses (ALDEx2, ANCOM\u2010BC, DESeq2, LEfSe, and MaAsLIN2) were used to compare microbiota composition between groups. The measurement of faecal short\u2010chain fatty acids (SCFAs) using gas chromatography evaluated the gut microbiota functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight allergic patients were included (median age: 1.3\u2009years), and 22 became tolerant over time. Allergic patients exhibited lower gut and salivary alpha\u2010diversities, and several different genera (12 in stools, including less\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      , and 2 in saliva), and higher relative abundance of acetate than the controls. With tolerance acquisition, faecal alpha\u2010diversities partially increased, whereas SCFAs normalised. Ultimately, there were more differences in faecal and salivary microbiota in allergic patients versus after tolerance acquisition (i.e., more\n                      <jats:italic>Blautia<\/jats:italic>\n                      ,\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Prevotella<\/jats:italic>\n                      \u20109, and less\n                      <jats:italic>Escherichia<\/jats:italic>\n                      \u2013\n                      <jats:italic>Shigella<\/jats:italic>\n                      in tolerant patients) than between the controls over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The faecal and salivary dysbiosis observed in allergic patients with FPIES partially resolved after tolerance acquisition. Understanding the underlying mechanisms of dysbiosis is crucial to prevent and help manage FPIES. A prolonged follow\u2010up could determine whether dysbiosis resolution may be complete, and whether this early infancy dysbiosis has long\u2010term consequences on health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70363","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:56:52Z","timestamp":1777435012000},"page":"3608-3619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Follow\u2010Up of Gut and Salivary Microbiota in Children With Food Protein\u2010Induced Enterocolitis Syndrome"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7207","authenticated-orcid":false,"given":"Anais","family":"Lemoine","sequence":"first","affiliation":[{"name":"INRAe, Micalis Institute  Jouy\u2010en\u2010Josas France"},{"name":"Sorbonne Universit\u00e9, APHP\u2010Trousseau Hospital Pediatric Nutrition and Gastroenterology 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