{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:15:02Z","timestamp":1778037302474,"version":"3.51.4"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lupus panniculitis (LP) is a neglected, often treatment\u2010refractory subtype of cutaneous lupus erythematosus. It is characterized by inflammation of subcutaneous adipose tissue, and the pathomechanisms are poorly understood. We sought to explore the cellular and molecular signatures of LP and their relationship to systemic lupus erythematosus. We performed imaging mass cytometry (IMC; LP\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098, Healthy Control (HC)\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) and targeted transcript profiling by NanoString nCounter (Human Immunology Panel, 579 genes; LP\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099, HC\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099). LP lesions showed extensive septal leukocyte infiltration. The infiltrate consisted predominantly of T cells (48%), followed by B cells (14%) and antigen\u2010presenting cells (APCs). T cells exhibited a cytotoxic (CD8\n                    <jats:sup>+<\/jats:sup>\n                    , GranzymeB\n                    <jats:sup>+<\/jats:sup>\n                    ) and skin\u2010homing (CLA\n                    <jats:sup>+<\/jats:sup>\n                    ) phenotype, with upregulation of Th1 markers. They closely interacted with M1 macrophages. B cells displayed strong spatial interactions with na\u00efve T cells. NanoString analyses revealed upregulation of T\u2010 and B\u2010cell receptor signaling pathway genes, antigen presentation\u2010related genes (MHC\u2010I\/II), and Th1 associated programs (STAT1\/IRF1), together with activation of innate immune, complement, and pattern\u2010recognition receptor pathways. This was paralleled by strong upregulation of IDO1, a key enzyme in tryptophan metabolism, and inversely correlated, reduced AHR expression. Our data provide new pathomechanistic insights into LP, highlighting overlaps with systemic lupus, but also LP\u2010specific features. This may pave the way for adopting more targeted treatment approaches for LP.\n                  <\/jats:p>","DOI":"10.1111\/all.70377","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:44:12Z","timestamp":1778035452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1\u2010Skewed T\u2010Cell Response With Signs of Metabolic Alteration"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6031-9872","authenticated-orcid":false,"given":"Milad","family":"Ameri","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Christine K\u00fchne Center for Allergy Research and Education CK\u2010CARE  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-6725","authenticated-orcid":false,"given":"Reihane","family":"Ziadlou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Christine K\u00fchne Center for Allergy Research and Education CK\u2010CARE  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Traidl","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Department of Dermatology and Allergy Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Sokolowska","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Contassot","sequence":"additional","affiliation":[{"name":"Department of Biomedicine University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Christine K\u00fchne Center for Allergy Research and Education CK\u2010CARE  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maija","family":"Kiuru","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California  Davis California USA"},{"name":"Department of Pathology University of California  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Kolm","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Kempf","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Kempf Und Pfaltz Histologische Diagnostik  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanual","family":"Maverakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezmi","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-6254","authenticated-orcid":false,"given":"Marie\u2010Charlotte","family":"Br\u00fcggen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich (USZ)  Zurich Switzerland"},{"name":"Christine K\u00fchne Center for Allergy Research and Education CK\u2010CARE  Davos Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00000372-200012000-00009","article-title":"Panniculitis: Definition of Terms and Diagnostic Strategy","volume":"22","author":"Cascajo C. 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