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In this study, we sought to elucidate the role of MAIT cells in a T cell\u2010dominant model of allergic asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a murine model of house dust mite\u2013induced asthma and a selective MAIT cell antagonist (Acetyl\u20106\u2010formylpterin, A6FP) to inhibit MAIT cell activation in\u00a0vivo. Airway hyperresponsiveness, lung inflammation, serum IgE, and cytokine profiles were assessed. In\u00a0vitro co\u2010culture experiments evaluated the direct impact of MAIT cells on B cell IgE production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pharmacologic inhibition of MAIT cells exacerbated airway hyperresponsiveness and elevated circulating IgE without altering airway eosinophilia or T helper type 2\/type 17 cytokine production. MAIT cell antagonism failed to increase AHR in IgE\u2010deficient mice. In\u00a0vitro, activated MAIT cells directly suppressed B cell IgE production through IFN\u03b3 signaling. IL\u20104 was sufficient to enhance IFN\u03b3 production by MAIT cells, suggesting that allergic inflammation may induce a counter\u2010regulatory response from MAIT cells to limit IgE\u2010mediated pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAIT cells limit airway hyperresponsiveness by suppressing IgE production through IFN\u03b3\u2013dependent B cell regulation. These findings define a previously unrecognized immunoregulatory function of MAIT cells in allergic asthma and suggest that enhancing MAIT cell activity may represent a therapeutic strategy for IgE\u2010mediated diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70384","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:50:36Z","timestamp":1778147436000},"page":"3236-3249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MAIT<\/scp>\n                    Cells Suppress\n                    <scp>IgE<\/scp>\n                    \u2010Mediated Asthma via\n                    <scp>IFN\u03b3<\/scp>\n                    \u2010Dependent B Cell Regulation"],"prefix":"10.1111","volume":"81","author":[{"given":"Angela M.","family":"Cannata","sequence":"first","affiliation":[{"name":"Immunology Graduate Program University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn W.","family":"McAlees","sequence":"additional","affiliation":[{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Hargis","sequence":"additional","affiliation":[{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8870-9262","authenticated-orcid":false,"given":"Archana","family":"Shankar","sequence":"additional","affiliation":[{"name":"Immunology Graduate Program University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouxiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Host\u2010Pathogen Interactions Program Texas Biomedical Research Institute  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senad","family":"Divanovic","sequence":"additional","affiliation":[{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Center for Inflammation and Tolerance Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Lewkowich","sequence":"additional","affiliation":[{"name":"Division of Immunobiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00263"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00536-2015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08901-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.029"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00010401"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2044278"},{"key":"e_1_2_10_9_1","volume-title":"Current Topics in Microbiology and Immunology","author":"Curotto de Lafaille M. 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