{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:28:01Z","timestamp":1787668081405,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab has shown efficacy in patients with uncontrolled CRSwNP in clinical trials and real\u2010world practice, but data in Chinese patients are limited. This study investigated the efficacy and safety of dupilumab in Chinese patients with severe CRSwNP who were not controlled on standard of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This placebo\u2010controlled, Phase III trial randomized patients 1:1 to dupilumab 300\u2009mg every 2\u2009weeks or matching placebo for 24\u2009weeks as add\u2010on treatment with daily intranasal corticosteroids. The primary efficacy endpoint was change from baseline in nasal polyp score (NPS) at week 24. Patient\u2010reported outcomes and safety were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      63 patients were randomized (dupilumab\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931, placebo\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932). Baseline characteristics were well balanced between the groups. Improvement in NPS at week 24 was significantly greater with dupilumab than placebo (least square mean difference [LSMD] \u22121.84 [95% CI \u22122.53, \u22121.15],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Dupilumab also improved patient\u2010reported outcomes vs. placebo: nasal congestion score (LSMD \u22120.54 [95% CI \u22120.97, \u22120.12],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0126); total symptom score (\u22121.68 [\u22122.67, \u22120.69],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008); loss of smell score (\u22120.62 [\u22121.08, \u22120.17],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0072); and health\u2010related quality of life (22\u2010item sino\u2010nasal outcome test score) (\u22129.52 [\u221216.81, \u22122.24],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0104). The incidence of treatment\u2010emergent adverse events was similar between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dupilumab is efficacious in Chinese patients with CRSwNP, with tolerability consistent with the known safety profile. These results support the benefits of dupilumab in Chinese patients with severe CRSwNP who are uncontrolled on standard of care therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05878093\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70414","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:23:52Z","timestamp":1781601832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo\u2010Controlled, Phase\n                    <scp>III<\/scp>\n                    Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-6314","authenticated-orcid":false,"given":"Mu","family":"Xian","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-1584","authenticated-orcid":false,"given":"Menglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shanxi Medical University Second Affiliated Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jingzhou Hospital Affiliated to Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rhinology and Allergy, Otolaryngology\u2010Head and Neck Surgery Centre Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-4485","authenticated-orcid":false,"given":"Juan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, West China School of Medicine West China Hospital Sichuan University Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1000-9903","authenticated-orcid":false,"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-1318","authenticated-orcid":false,"given":"Xicheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Yantai Yuhuangding Hospital, Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-7876","authenticated-orcid":false,"given":"Li","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Ling","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Li","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Fontenot","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey R.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-275X","authenticated-orcid":false,"given":"Neelam A.","family":"Phadke","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-5135","authenticated-orcid":false,"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00218-1"},{"issue":"29","key":"e_1_2_11_3_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. 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