{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:44:39Z","timestamp":1782701079148,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00044"],"award-info":[{"award-number":["PI19\/00044"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01095"],"award-info":[{"award-number":["PI19\/01095"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01273"],"award-info":[{"award-number":["PI19\/01273"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD24\/0007"],"award-info":[{"award-number":["RD24\/0007"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Food allergy (FA) significantly impairs health\u2010related quality of life (HRQL), yet its key determinants remain unclear. This study aimed to identify factors associated with poor HRQL in FA using machine\u2010learning analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within the Spanish multicentre BIOGRIAL study, well\u2010phenotyped patients with IgE\u2010mediated FA were enrolled. Participants aged \u2265\u20098\u2009y were included to allow self\u2010completion of the Food Allergy Quality of Life Questionnaire (FAQLQ). Clinical variables included atopic comorbidities, number and type of food allergies, age at onset, FA duration, need for urgent treatment, and reaction severity graded with the Food Allergy Severity Score. Poor FA\u2010HRQL was defined as FAQLQ \u2265\u20095 (range 1\u20137). Determinants were identified using logistic regression and decision trees.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 502 patients were included (63.9% female, 86% adults, 7.4% adolescents, 6.6% children). Median FAQLQ was 4.55. Adults and females had poorer FA\u2010HRQL than younger participants and males, respectively. Logistic regression identified female sex, multiple allergies, severe reactions, and vegetable allergy as independent predictors. Decision trees identified adult age, female sex, number of food allergies, need for urgent care, reaction severity, and FA onset &lt;\u200918\u2009y as determinants of poor FA\u2010HRQL. Adult females with \u2265\u20097 food allergies had the worst FA\u2010HRQL (mean FAQLQ 5.93), and 79% of patients with FAQLQ \u2265\u20095 were adult females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HRQL of people with FA is impaired by multiple determinants that should be addressed through psychosocial support, dietary management and education. Being female was the determinant with the highest negative impact, and adult women with multiple FAs have the poorest FA\u2010HRQL and require targeted personalised interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70418","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:35:52Z","timestamp":1781926552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Poor Health\u2010Related Quality of Life in Patients With Food Allergy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8623-6326","authenticated-orcid":false,"given":"Rosialzira Natasha","family":"Vera\u2010Berrios","sequence":"first","affiliation":[{"name":"Allergy Dept, Hospital Cl\u00ednico San Carlos IDISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-1896","authenticated-orcid":false,"given":"Alejandro","family":"Gonzalo\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Allergy Research Group IDISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8476-1381","authenticated-orcid":false,"given":"Natalia","family":"Freundt\u2010Serpa","sequence":"additional","affiliation":[{"name":"Allergy Dept, Hospital Cl\u00ednico San Carlos IDISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-3274","authenticated-orcid":false,"given":"Guadalupe","family":"Marco\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Allergy Dept, Hospital Cl\u00ednico San Carlos IDISSC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6039-928X","authenticated-orcid":false,"given":"Beatriz","family":"Fern\u00e1ndez\u2010Parra","sequence":"additional","affiliation":[{"name":"Allergy Dept. 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