{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:53:01Z","timestamp":1782219181745,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["542\/20"],"award-info":[{"award-number":["542\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Israel Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["01039502"],"award-info":[{"award-number":["01039502"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Eosinophilic gastritis (EoG) is a chronic inflammatory disease characterized by infiltration of eosinophils and mast cells, epithelial remodeling, and fibrosis. Although EoG is increasingly recognized as a distinct type 2 inflammatory disease, the cellular and molecular events that drive disease pathogenesis remain poorly understood. This is due in part to the absence of robust and physiologically relevant experimental models that recapitulate human disease<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Experimental EoG was induced in wild\u2010type and\n                      <jats:italic>Il13ra1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mice by repeated intragastric oxazolone challenges in skin\u2010sensitized mice. IL\u20104R\u03b1 was neutralized using antibodies. Gastric histopathology was determined by H&amp;E, anti\u2010Ki67, chloroacetate esterase, and anti\u2010MBP staining. Gastric RNA was subjected to RNA sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Experimental EoG resulted in robust gastric eosinophilia, mastocytosis, epithelial remodeling, and subepithelial fibrosis. Transcriptomic profiling of gastric tissue revealed broad upregulation of type 2 cytokine and epithelial\u2010remodeling genes, including\n                      <jats:italic>Il4ra<\/jats:italic>\n                      ,\n                      <jats:italic>Il4i1, Ccl5, Muc4, Mmp10<\/jats:italic>\n                      ,\n                      <jats:italic>Mcpt1\/2, Areg, Pparg<\/jats:italic>\n                      , and\n                      <jats:italic>Tff2<\/jats:italic>\n                      . The transcriptome profile of experimental EoG was markedly distinct from that of experimental EoE despite both models being initiated by oxazolone, suggesting that identical inflammatory triggers elicit tissue\u2010specific and context\u2010dependent transcriptional programs. Blockade of IL\u20104R\u03b1 signaling abrogated both eosinophil and mast cell infiltration and attenuated epithelial remodeling, whereas genetic deletion of\n                      <jats:italic>Il13ra1<\/jats:italic>\n                      selectively suppressed epithelial remodeling without affecting inflammatory cell recruitment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings establish experimental EoG as a robust model for dissecting the cellular and molecular mechanisms driving gastric type 2 inflammation. They further define receptor\u2010specific roles for IL\u20104R\u03b1 and IL\u201013R\u03b11 in coordinating immune infiltration and epithelial remodeling in EoG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70420","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:35:31Z","timestamp":1781782531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Roles for\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>4R\u03b1<\/scp>\n                    and\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>13R\u03b11<\/scp>\n                    in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis"],"prefix":"10.1111","author":[{"given":"Anish","family":"Dsilva","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Barakey","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences Tel\u2010Aviv University  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