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Melittin, the principal component of HBV, accounts for 40%\u201350% of its dry weight and is responsible for most of its biological activity. Beyond its well\u2010established role as a potent allergen and mast cell activator, melittin displays broad anti\u2010tumour properties across multiple cancer models. Preclinical evidence demonstrates that melittin induces cancer cell death through membrane disruption, mitochondrial and death receptor\u2013mediated apoptosis, ferroptosis, and inhibition of key oncogenic pathways, including PI3K\/Akt\/mTOR, NF\u2010\u03baB, and HIF\u20101\u03b1\/VEGF signalling. Additional effects include suppression of angiogenesis, epithelial\u2013mesenchymal transition, invasion, and metastatic dissemination, as well as modulation of the tumour immune microenvironment. However, the clinical translation of melittin is limited by its intrinsic haemolytic activity, systemic toxicity, and high allergenic potential. Advances in nanotechnology, targeted delivery systems, and venom\u2010inspired peptide engineering are addressing these barriers, enabling tumour\u2010selective delivery while reducing off\u2010target effects. This EAACI Task Force Position Paper integrates current evidence on melittin within the emerging field of AllergoOncology. It highlights its dual relevance for allergists and oncologists and outlines the translational challenges to be overcome and opportunities to enable safe clinical application.<\/jats:p>","DOI":"10.1111\/all.70421","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:40:06Z","timestamp":1782272406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melittin in\n                    <scp>A<\/scp>\n                    llergo\n                    <scp>O<\/scp>\n                    ncology: From Honey Bee Venom to Anti\u2010Cancer Therapeutic Innovation\u2014An\n                    <scp>EAACI<\/scp>\n                    Position Paper"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-0507","authenticated-orcid":false,"given":"Teodorikez\u2010Wilfox","family":"Jimenez\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Allergy Section, Dr. Balmis General University Hospital Alicante Institute for Health and Biomedical Research (ISABIAL)  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-0791","authenticated-orcid":false,"given":"Luljeta","family":"Ahmetaj","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Pristina  Pristina Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-0586","authenticated-orcid":false,"given":"Teresa","family":"Alfaya Arias","sequence":"additional","affiliation":[{"name":"Allergy Unit University Hospital Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-1114","authenticated-orcid":false,"given":"Elisa","family":"Boni","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit Maggiore Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6081-4980","authenticated-orcid":false,"given":"Lali","family":"Bugadze","sequence":"additional","affiliation":[{"name":"Georgian National University SEU  Tbilisi Georgia"},{"name":"Todua Clinic  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-9234","authenticated-orcid":false,"given":"Jitesh","family":"Chauhan","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; 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