{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:16:28Z","timestamp":1783322188580,"version":"3.54.6"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002649"],"award-info":[{"award-number":["UL1TR002649"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["R56AI139658"],"award-info":[{"award-number":["R56AI139658"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL162991"],"award-info":[{"award-number":["R01HL162991"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Initiation of allergic responses requires activation of specialized subsets of T follicular helper (Tfh) cells called Tfh13 cells. Differentiation of these cells from na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells is induced by antigen presenting cells, such as type 2 conventional dendritic cells (cDC2s), following allergen exposure. Here we show that allergen stimulation induces a distinct metabolic program in cDC2s characterized by increased glutaminolysis which results in intracellular accumulation of \u03b1\u2010ketoglutarate. Inhibition of glutaminolysis suppresses Tfh13 cell differentiation and promotes inhibitory T follicular regulatory (Tfr) cell activation in\u00a0vivo. Further, glutamine\u2010derived \u03b1\u2010ketoglutarate in cDC2s regulates Tfh13 polarization by modulation of JmjD3 mediated histone demethylation and modulation of HIF\u20101\u03b1 activity. JmjD3 or HIF\u2010prolyl hydroxylase (HIF\u2010PH) blockade reduced Tfh13 and germinal center IgE production. Genetic deletion of HIF\u20101\u03b1 in cDCs, in contrast, enhanced Tfh13 polarization and IgE synthesis. Finally, we show that glutaminase or HIF\u2010PH inhibitor treatment in allergen\u2010sensitized mice induces allergen tolerance characterized by reduced asthmatic airway resistance, antigen\u2010specific IgE production, and airway mast cell degranulation. Thus, we demonstrate that \u03b1\u2010ketoglutarate production regulates epigenetic and gene expression changes critical for allergic sensitization by cDC2s following allergen exposure, leading to induction of Tfh13 cells and antigen\u2010specific IgE formation. Therefore, this glutaminase 1\u2010JmjD3\/HIF\u2010PH axis represents a promising new target for controlling IgE\u2010mediated allergic disease pharmacologically.\n                  <\/jats:p>","DOI":"10.1111\/all.70427","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:58:35Z","timestamp":1783321115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dendritic Cell \u03b1\u2010Ketoglutarate Regulates Tfh Polarization in Allergy"],"prefix":"10.1111","author":[{"given":"Anuj","family":"Tharakan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Camarena","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araba","family":"Abaidoo\u2010Myles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Allegood","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Virginia Commonwealth University  Richmond Virginia 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-208X","authenticated-orcid":false,"given":"Stephanie C.","family":"Eisenbarth","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Landry","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-5463","authenticated-orcid":false,"given":"Rebecca 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