{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:08:08Z","timestamp":1791486488361,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["CEX2021\u2010001189\u2010S\u201020\u20101"],"award-info":[{"award-number":["CEX2021\u2010001189\u2010S\u201020\u20101"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early\u2010life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture\u2010based and\/or culture\u2010independent methods (including sequencing\u2010based approaches) to subsequent FA or food sensitization outcomes in infants, children, and adolescents up to 18\u2009years of age. PubMed, Web of Science Core Collection, Embase, Scopus, and LILACS were searched from database inception to March 2026. Inclusion required microbiota sampling during pregnancy or childhood and clinically ascertained FA\/sensitization; non\u2010human studies and studies without sequencing or clinical outcomes were excluded. Risk of bias was assessed using QUIPS. Owing to heterogeneity, we performed narrative synthesis. Forty studies were included (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096530 participants; 2077 cases). Across cohorts, cases were associated with lower diversity, early beta\u2010divergence (1\u20136\u2009months), neonatal enrichment of Proteobacteria (Pseudomonadota)\/Enterobacteriaceae and selected taxa (\n                    <jats:italic>Clostridium<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Sutterella<\/jats:italic>\n                    ), and depletion within the first year of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    , and butyrate producers (\n                    <jats:italic>Roseburia<\/jats:italic>\n                    ,\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    ). Functional profiles often suggested delayed maturation and reduced short\u2010chain fatty acid capacity. Evidence was limited by moderate risk of bias, residual confounding, and heterogeneous outcome definitions. These findings support distinct early\u2010life microbial configurations associated with FA susceptibility versus tolerance, informing mechanism\u2010based prevention.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO CRD420251234739.\n                  <\/jats:p>","DOI":"10.1111\/all.70433","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:47:01Z","timestamp":1784879221000},"page":"3453-3471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-7181","authenticated-orcid":false,"given":"Eduard Flores","family":"Ventura","sequence":"first","affiliation":[{"name":"Department of Biotechnology Institute of Agrochemistry and Food Technology\u2010National Research Council (IATA\u2010CSIC)  Valencia Spain"},{"name":"PhD Program in Biotechnology Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Corriger","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR\u2010S1135, Centre D'immunologie et Des Maladies Infectieuses (CIMI\u2010Paris)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Omer","sequence":"additional","affiliation":[{"name":"Chair of Nutrition and Immunology, School of Life Sciences Technical University of Munich  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bodinier","sequence":"additional","affiliation":[{"name":"INRAE, UR BIA, Nantes  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Haller","sequence":"additional","affiliation":[{"name":"Chair of Nutrition and Immunology, School of Life Sciences Technical University of Munich  Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Hertz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Vaccine and Infectious Disease Division Fred Hutch Cancer Research Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Larsen","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR\u2010S1135, Centre D'immunologie et Des Maladies Infectieuses (CIMI\u2010Paris)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-4864","authenticated-orcid":false,"given":"Maria Carmen","family":"Collado","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Institute of Agrochemistry and Food Technology\u2010National Research Council (IATA\u2010CSIC)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(25)00003\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(24)00186\u20105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16429"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15828"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16611"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjnph\u20102023\u2010000680"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2023.100420"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040336\u20104"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.101042"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.08.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"E.Flores Ventura J.Corriger M.Bodinier et\u00a0al. \u201cMicrobiota Signatures Associated With Infant Food Allergy: A Systematic Review and Meta\u2010Analysis \u201dPROSPERO(2025) https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251234739.","DOI":"10.1111\/all.70433"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.021"},{"key":"e_1_2_11_15_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"McKenzie J. 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