{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:16:04Z","timestamp":1783055764378,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgE\u2010mediated food allergy prevention guidelines are now established in many countries, but their implementation in routine clinical practice globally remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An anonymous online survey was distributed to healthcare professionals (HCPs) through the World Allergy Organization network between December 2024 and April 2025, collecting data on food allergy prevention recommendations in daily clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 731 healthcare professionals from 80 countries worldwide: Asia (36.7%), Europe (27.1%), North America (15.9%), and Rest of the World (20.0%; Russia, South America, Africa, Oceania). Unsupervised clustering revealed two distinct practice patterns\u2014one favoring early allergen introduction and one favoring later introduction\u2014with timing varying by allergen type. For peanuts, clusters diverged between early (median 6\u2009months of age) and late (median 18\u2009months of age) introduction recommendations for high\u2010risk infants. Allergen introduction timing was independently driven by region and specialty: North American HCPs recommend peanut introduction 6.7\u2009months earlier than those in Asia (5.48  3.32 vs. 12.18  7.27\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and pediatric allergists globally advocate for introduction 2.37\u2009months earlier than non\u2010allergists (8.72  5.85 vs. 11.09  7.14\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024). This disparity is more pronounced in high\u2010risk infants than in normal\u2010risk infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The variability in allergen introduction practices, driven by geography and medical specialty, highlights a persistent gap in prevention guidelines adoption. This divergence likely reflects both suboptimal implementation of existing recommendations and regional differences in food allergy epidemiology. These findings underscore the need for population\u2010tailored allergen introduction strategies across diverse healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70435","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:22:11Z","timestamp":1783052531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-4478","authenticated-orcid":false,"given":"Agnes Sze\u2010yin","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong 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of Medicine and Health Research Methods Evidence and Impact, McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-3222","authenticated-orcid":false,"given":"Matthew","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7294","authenticated-orcid":false,"given":"Daria","family":"Levina","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Paediatric Infectious Diseases Institute of Child's Health, Sechonov First Moscow State Medical University  Moscow 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Arnaud de Villeneuve, University Hospital of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-0228","authenticated-orcid":false,"given":"Carmen","family":"Riggioni","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy The Hospital for Sick Children and the SickKids Food Allergy and Anaphylaxis Program  Toronto Ontario Canada"},{"name":"Department of Paediatrics, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-3206","authenticated-orcid":false,"given":"Elsy M.","family":"Navarrete\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology WAO Center of Excellence, Hospital Infantil de M\u00e9xico Federico Gomez  Mexico City 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