{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:28:09Z","timestamp":1786328889835,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Despite adequate local treatment, chronic rhinosinusitis with nasal polyps (\n CRSwNP<\/jats:styled-content>\n ) may remain uncontrolled and necessitate endoscopic sinus surgery (\n ESS<\/jats:styled-content>\n ). It remains unclear what extent of\n ESS<\/jats:styled-content>\n is most effective. This trial compares two common surgical approaches: full and limited functional\n ESS<\/jats:styled-content>\n (\n FESS<\/jats:styled-content>\n ) in patients with\n CRSwNP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n AirGOs<\/jats:styled-content>\n Operative is a randomised, controlled trial performed in two university hospitals. Patients with a total Sino\u2010nasal\u2010outcome\u2010test (\n SNOT<\/jats:styled-content>\n \u201022) score \u2265\u200930, bilateral nasal polyp score \u2265\u20094, modified Lund\u2010Mackay radiological score \u2265\u200914, and previous surgery or systemic medication for\n CRSwNP<\/jats:styled-content>\n were included. The primary outcome measure was the change in disease\u2010specific health\u2010related quality of life measure\n SNOT<\/jats:styled-content>\n \u201022 between the baseline and 12\u2010 and 24\u2010month follow\u2010ups.\n <\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n Between Oct 23, 2018 and Oct 12, 2022, 97 patients were recruited. The per protocol analysis included 47 patients in the full\n FESS<\/jats:styled-content>\n group and 47 patients in the limited\n FESS<\/jats:styled-content>\n group. At 12\u2009months, the mean\n SNOT<\/jats:styled-content>\n \u201022 score was 22.3 (\n SD<\/jats:styled-content>\n 15.7) in the full\n FESS<\/jats:styled-content>\n group and 31.5 (\n SD<\/jats:styled-content>\n 18.8) in the limited\n FESS<\/jats:styled-content>\n group yielding a mean difference of \u22129.2. At 24\u2009months, the mean\n SNOT<\/jats:styled-content>\n \u201022 scores were 25.3 (\n SD<\/jats:styled-content>\n 16.9) and 27.8 (\n SD<\/jats:styled-content>\n 21.6), respectively, with a mean difference of \u22122.5. However, the difference in change of total\n SNOT<\/jats:styled-content>\n \u201022 scores between the groups was insignificant and did not exceed the minimal clinically important difference. Several secondary outcome measures, amongst which olfaction and polyp load, showed differences in improvement between the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n Full and limited\n FESS<\/jats:styled-content>\n are both effective in improving\n HRQoL<\/jats:styled-content>\n in patients with\n CRSwNP<\/jats:styled-content>\n within 24\u2009months. Decrease in total\n SNOT<\/jats:styled-content>\n \u201022 scores exceeded the minimal clinically meaningful difference in both groups, but this difference was not met between the groups at 12 or 24\u2009months. Postoperative differences between the groups in secondary outcomes may represent better inflammatory control after full\n FESS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n , NCT03704415. Registered on the 8th October 2018\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.70438","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:12:41Z","timestamp":1785417161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-5201","authenticated-orcid":false,"given":"P.","family":"Virkkula","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hammar\u00e9n\u2010Malmi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Laulajainen\u2010Hongisto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lilja","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-805X","authenticated-orcid":false,"given":"J.","family":"Wikst\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-4357","authenticated-orcid":false,"given":"L.","family":"Hafr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Helsinki University Hospital, and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-330X","authenticated-orcid":false,"given":"P.","family":"Kauppi","sequence":"additional","affiliation":[{"name":"Pulmonary Diseases Heart and Lung Center, University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Reitsma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head\/Neck Surgery Amsterdam UMC, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pajala","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kuopio University Hospital, Wellbeing Services County of North Savo Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sahlman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kuopio University Hospital, Wellbeing Services County of North Savo Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6686","authenticated-orcid":false,"given":"S.","family":"Toppila\u2010Salmi","sequence":"additional","affiliation":[{"name":"Pulmonary Diseases Heart and Lung Center, University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Department of Otorhinolaryngology Kuopio University Hospital, Wellbeing Services County of North Savo Kuopio Finland"},{"name":"Department of Otorhinolaryngology University of Eastern Finland and the Wellbeing Services County of North Savo Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"29","key":"e_1_2_13_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. 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