{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:07:18Z","timestamp":1789092438799,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102024\u201000403375"],"award-info":[{"award-number":["RS\u20102024\u201000403375"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early\u2010stage mycosis fungoides (MF) often presents diagnostic challenges because of its clinical overlap with atopic dermatitis (AD). In clinical practice, we encountered a subset of patients with severe AD who fulfilled the MF diagnostic criteria yet remained clinically indistinguishable from AD and presented refractoriness to advanced therapies. We termed this ambiguous entity \u201cmycosis fungoides\u2010like AD\u201d (mfAD) and sought to determine whether it represents malignant transformation or a distinct inflammatory endotype of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Skin biopsies were obtained from 7 patients with AD and 11 patients with mfAD. We performed paired single\u2010cell RNA sequencing and single\u2010cell T\u2010cell receptor sequencing analyses. Publicly available MF and AD datasets were integrated for comparative analysis. Spatial transcriptomic profiling was used to contextualize single\u2010cell findings within the tissue architecture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparative transcriptomic analysis revealed that T cells in mfAD were aligned with those in AD and lacked genomic instability. High\u2010resolution profiling showed that mfAD was characterized by oligoclonal Th22 expansion rather than a single dominant malignant clone. Notably, all patients with mfAD achieved rapid clinical remission with selective JAK1 inhibition, indicating the therapeutic response characteristics of inflammatory dermatoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that mfAD is not a true malignancy, but rather a Th22\u2010driven inflammatory endotype of AD. These results redefine mfAD as an inflammatory subtype within the AD spectrum, providing a mechanistic explanation for both the \u201cpseudo\u2010monoclonality\u201d that leads to MF misdiagnosis and the failure of dupilumab. This study establishes a rationale for the use of JAK inhibitors in precision medicine for this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.70440","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:30:24Z","timestamp":1786023024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mycosis Fungoides\u2010Like Atopic Dermatitis Represents a Th22\u2010Dominant Inflammatory Endotype"],"prefix":"10.1111","author":[{"given":"Jung Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University Graduate School  Seoul Republic of Korea"},{"name":"Cancer Research Institute, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ha","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine  Wonju Republic of Korea"},{"name":"Department of Physiology Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungdon","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Jun","family":"Kang","sequence":"additional","affiliation":[{"name":"Organelle Medicine Research Center, Yonsei University Wonju College of Medicine  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geon","family":"Lee","sequence":"additional","affiliation":[{"name":"Transplantation Research Institute, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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