{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:08:01Z","timestamp":1784858881929,"version":"3.55.0"},"reference-count":201,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009794","name":"Breast Cancer Now","doi-asserted-by":"publisher","award":["KCL\u2010Q4\u2010Y1"],"award-info":[{"award-number":["KCL\u2010Q4\u2010Y1"]}],"id":[{"id":"10.13039\/100009794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000325","name":"Wellbeing of Women","doi-asserted-by":"publisher","award":["RG2562"],"award-info":[{"award-number":["RG2562"]}],"id":[{"id":"10.13039\/501100000325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000296","name":"British Skin Foundation","doi-asserted-by":"publisher","award":["006\/R\/22"],"award-info":[{"award-number":["006\/R\/22"]}],"id":[{"id":"10.13039\/501100000296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["24\u20100087"],"award-info":[{"award-number":["24\u20100087"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule\u2010associated mediators including histamine and lipid mediators such as LTC\n                    <jats:sub>4<\/jats:sub>\n                    , while cytokine production occurs over a longer timescale, contributing to downstream immune responses. Basophil activation is driven by IgE\u2010dependent Fc\u03b5RI crosslinking or IL\u20103, complement and Toll\u2010like receptor (TLR) pathways, enabling diverse effector responses, including type I hypersensitivity to allergens. Through IL\u20104 and IL\u201013 secretion, basophils bridge innate and adaptive immunity, promoting Th2 differentiation, B cell activation and recruiting eosinophils. Beyond allergy, basophils contribute to inflammation, angiogenesis, cancer immune surveillance and tumour progression. Basophils participate in IgE\u2010dependent type I hypersensitivity to small\u2010molecule drugs, chemotherapeutics and monoclonal antibodies, becoming activated when drugs cross\u2010link specific IgE\u2013Fc\u03b5RI complexes, driving rapid mediator release and amplifying Th2\u2010skewed inflammation. The basophil activation test (BAT), which quantifies activation markers, such as CD63 and CD203c, provides an ex\u00a0vivo functional measurement of these responses and serves as a biomarker of IgE\u2010mediated hypersensitivity. In oncology, BAT is applied to predict and monitor hypersensitivity reactions, drug desensitisation and support IgE\u2010based therapeutics development. Collectively, basophils are emerging as pivotal immune regulators and BAT presents a mechanistic, clinically\u2010actionable tool for advancing precision medicine in AllergoOncology.\n                  <\/jats:p>","DOI":"10.1111\/all.70457","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:49:12Z","timestamp":1784857752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basophils in Immunity: Activation Pathways, Roles in Allergy and\n                    <scp>AllergoOncology<\/scp>\n                    and Application of the Basophil Activation Test"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-9234","authenticated-orcid":false,"given":"Jitesh","family":"Chauhan","sequence":"first","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4262-2397","authenticated-orcid":false,"given":"Sofia","family":"Vlasova","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-9268","authenticated-orcid":false,"given":"Alicia","family":"Chenoweth","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"},{"name":"Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences King's College London, Guy's Cancer Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra H.","family":"Josephs","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"},{"name":"Cancer Centre Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-4160","authenticated-orcid":false,"given":"Heather J.","family":"Bax","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-7810","authenticated-orcid":false,"given":"Sophia N.","family":"Karagiannis","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology, School of Basic and Medical Biosciences &amp; KHP Centre for Translational Medicine King's College London, Guy's Hospital  London UK"},{"name":"Breast Cancer Now Research Unit, School of Cancer and Pharmaceutical Sciences King's College London, Guy's Cancer Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-35723-8_2","article-title":"Basophils in Tumor Microenvironment and Surroundings","volume":"1224","author":"Marone G.","year":"2020","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"12","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/intimm\/dxab021","article-title":"Basophils, a Neglected Minority in the Immune System, Have Come Into the Limelight at Last","volume":"33","author":"Karasuyama H.","year":"2021","journal-title":"International Immunology"},{"issue":"2","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, Mast Cells, Basophils, and Eosinophils","volume":"125","author":"Stone K. 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